Small nucleolar RNA SNORD66

Small nucleolar RNA SNORD66
Predicted secondary structure and sequence conservation of SNORD66
Identifiers
Symbol	SNORD66
Alt. Symbols	snoHBII-142
Rfam	RF00572
Other data
RNA type	Gene; snRNA; snoRNA; C/D-box
Domain(s)	Eukaryota
GO	0006396 0005730
SO	0000593

SNORD66 (also known as HBII-142) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

HBII-142 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.

HBII-142 is the human orthologue of the mouse MBII-142 snoRNA and is predicted to guide 2'O-ribose methylation of 18S ribosomal RNA (rRNA) at residue C1272.

An experiment that looked at 22 different non-small-cell lung cancer tissues found that SNORD33, SNORD66 and SNORD76 were over-expressed relative to matched noncancerous lung tissues.

External links

• Page for Small nucleolar RNA SNORD66 at Rfam
• Entry for SNORD66 at snoRNABase