Sialyl-Lewis A
The correct title of this article is Sialyl-LewisA. It appears incorrectly here because of technical restrictions.
| Sialyl-Lewis A | |
|---|---|
| Identifiers | |
| CAS number | 92448-22-1 |
| MeSH | sialyl+Lewis+A |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C31H52N2O23 |
| Molar mass | 820.74 g mol−1 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
Sialyl LewisA, also known as sialyl LeA and SLeA, is a tetrasaccharide carbohydrate that is usually attached to O-glycans on the surface of cells. It is known to play a vital role in cell-to-cell recognition processes.
Occurrence of the Sialyl Lewis A antigen, detected with the CA19-9 antibody, is highly correlated advanced epithelial cancers, such as stage III and stage IV colorectal cancers.[1]
References
- ^ Matsui T, Kojima T, Suzuki H, Hamajima H, Nakazato H, Ito K, Nakao A, Sakamoto J. (June 2004). "Sialyl Lewisa Expression as a Predictor of the Prognosis of Colon Carcinoma Patients in a Prospective Randomized Clinical Trial". Japanese Journal of Clinical Oncology 34 (10): 588–593. doi:10.1093/jjco/hyh110.
