Santiago Oñate Laborde (b. Mexico City, 1949) is a Mexican lawyer and politician affiliated to the Institutional Revolutionary Party (PRI).
Santiago Oñate has served in several positions inside the PRI and in the Mexican government. He was elected to the Chamber of Deputies in 1985 and to the Federal District Legislative Assembly upon expiration of his term as a federal legislator in 1998. In 1991 and 1992 he served as Ambassador to the Organization of American States and, in 1993, as the head of the Environmental Attorney's Office (Procuraduría Federal de Protección al Medio Ambiente or PROFEPA). In 1995 he was designated President of the PRI. He served for President Carlos Salinas as the head of the Presidency's Office (Oficina de la Presidencia). President Ernesto Zedillo appointed him as Secretary of Labor. Oñate has also served as Ambassador to the United Kingdom and to the Netherlands.
He pursued studies at the London School of Economics and Social Sciences and at the University of Wisconsin.