SYBL1

Vesicle-associated membrane protein 7
PDB rendering based on 2dmw.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2DMW
Identifiers
Symbols	VAMP7; SYBL1; TI-VAMP; TIVAMP; VAMP-7
External IDs	OMIM: 300053 MGI: 1096399 HomoloGene: 4121 GeneCards: VAMP7 Gene
Gene Ontology Molecular function • protein binding • syntaxin binding Cellular component • cytoplasm • lysosomal membrane • endoplasmic reticulum membrane • Golgi apparatus • plasma membrane • integral to membrane • cell junction • transport vesicle membrane • phagocytic vesicle membrane • SNARE complex • late endosome membrane • neuron projection • intracellular membrane-bounded organelle • apical part of cell • synapse • phagocytic vesicle • perinuclear region of cytoplasm Biological process • autophagic vacuole fusion • ER to Golgi vesicle-mediated transport • post-Golgi vesicle-mediated transport • vesicle fusion • phagocytosis, engulfment • endosome to lysosome transport • cellular membrane organization • vesicle-mediated transport • calcium ion-dependent exocytosis • triglyceride transport • Golgi to plasma membrane protein transport • eosinophil degranulation • neutrophil degranulation • vesicle fusion with Golgi apparatus • regulation of protein targeting to vacuolar membrane Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6845	20955
Ensembl	ENSG00000124333	ENSMUSG00000051412
UniProt	P51809	P70280
RefSeq (mRNA)	NM_001145149	NM_011515
RefSeq (protein)	NP_001138621	NP_035645
Location (UCSC)	Chr X: 155.11 – 155.17 Mb	Chr GL456233.1: 0.01 – 0.04 Mb
PubMed search	[1]	[2]

Vesicle-associated membrane protein 7 (VAMP-7) is a protein that in humans is encoded by the VAMP7 gene.

Function

VAMP-7 is a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. VAMP-7 localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes.

Interactions

SYBL1 has been shown to interact with SNAP23 and AP3D1.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Galli T, Zahraoui A, Vaidyanathan VV, et al. (1998). "A Novel Tetanus Neurotoxin-insensitive Vesicle-associated Membrane Protein in SNARE Complexes of the Apical Plasma Membrane of Epithelial Cells". Mol. Biol. Cell 9 (6): 1437–48. PMC 25366. PMID 9614185. 
• Advani RJ, Yang B, Prekeris R, et al. (1999). "Vamp-7 Mediates Vesicular Transport from Endosomes to Lysosomes". J. Cell Biol. 146 (4): 765–76. doi:10.1083/jcb.146.4.765. PMC 2156136. PMID 10459012. 
• Matarazzo MR, Cuccurese M, Strazzullo M, et al. (2000). "Human and mouse SYBL1 gene structure and expression". Gene 240 (1): 233–8. doi:10.1016/S0378-1119(99)00375-3. PMID 10564831. 
• Ciccodicola A, D'Esposito M, Esposito T, et al. (2000). "Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region". Hum. Mol. Genet. 9 (3): 395–401. doi:10.1093/hmg/9.3.395. PMID 10655549. 
• Ward DM, Pevsner J, Scullion MA, et al. (2000). "Syntaxin 7 and VAMP-7 are Soluble N-Ethylmaleimide–sensitive Factor Attachment Protein Receptors Required for Late Endosome–Lysosome and Homotypic Lysosome Fusion in Alveolar Macrophages". Mol. Biol. Cell 11 (7): 2327–33. PMC 14922. PMID 10888671. 
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. 
• Antonin W, Holroyd C, Fasshauer D, et al. (2001). "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function". EMBO J. 19 (23): 6453–64. doi:10.1093/emboj/19.23.6453. PMC 305878. PMID 11101518. 
• Wade N, Bryant NJ, Connolly LM, et al. (2001). "Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells". J. Biol. Chem. 276 (23): 19820–7. doi:10.1074/jbc.M010838200. PMID 11278762. 
• Antonin W, Fasshauer D, Becker S, et al. (2002). "Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs". Nat. Struct. Biol. 9 (2): 107–11. doi:10.1038/nsb746. PMID 11786915. 
• Müller DJ, Schulze TG, Jahnes E, et al. (2002). "Association between a polymorphism in the pseudoautosomal X-linked gene SYBL1 and bipolar affective disorder". Am. J. Med. Genet. 114 (1): 74–8. doi:10.1002/ajmg.10115. PMID 11840509. 
• Bogdanovic A, Bennett N, Kieffer S, et al. (2002). "Syntaxin 7, syntaxin 8, Vti1 and VAMP7 (vesicle-associated membrane protein 7) form an active SNARE complex for early macropinocytic compartment fusion in Dictyostelium discoideum". Biochem. J. 368 (Pt 1): 29–39. doi:10.1042/BJ20020845. PMC 1222979. PMID 12175335. 
• Matarazzo MR, De Bonis ML, Gregory RI, et al. (2003). "Allelic inactivation of the pseudoautosomal gene SYBL1 is controlled by epigenetic mechanisms common to the X and Y chromosomes". Hum. Mol. Genet. 11 (25): 3191–8. doi:10.1093/hmg/11.25.3191. PMID 12444103. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Martinez-Arca S, Rudge R, Vacca M, et al. (2003). "A dual mechanism controlling the localization and function of exocytic v-SNAREs". Proc. Natl. Acad. Sci. U.S.A. 100 (15): 9011–6. doi:10.1073/pnas.1431910100. PMC 166429. PMID 12853575. 
• Di Leva F, Ferrante MI, Demarchi F, et al. (2004). "Human synaptobrevin-like 1 gene basal transcription is regulated through the interaction of selenocysteine tRNA gene transcription activating factor-zinc finger 143 factors with evolutionary conserved cis-elements". J. Biol. Chem. 279 (9): 7734–9. doi:10.1074/jbc.M308140200. PMID 14672948. 
• Rao SK, Huynh C, Proux-Gillardeaux V, et al. (2004). "Identification of SNAREs involved in synaptotagmin VII-regulated lysosomal exocytosis". J. Biol. Chem. 279 (19): 20471–9. doi:10.1074/jbc.M400798200. PMID 14993220. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.