SURF6

Surfeit locus protein 6 is a protein that in humans is encoded by the SURF6 gene.

SURF6
Identifiers
Aliases	SURF6, RRP14, surfeit 6
External IDs	OMIM: 185642 MGI: 98447 HomoloGene: 133981 GeneCards: SURF6
Gene location (Human) Chr. Chromosome 9 (human) Band 9q34.2 Start 133,328,776 bp End 133,336,188 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 A3|2 19.08 cM Start 26,778,640 bp End 26,792,891 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve gastrocnemius muscle substantia nigra temporal lobe small intestine amygdala hypothalamus skin of abdomen prefrontal cortex left adrenal gland Top expressed in external carotid artery internal carotid artery primitive streak ascending aorta supraoptic nucleus aortic valve lacrimal gland hair follicle prostate cumulus cell More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein binding RNA binding Cellular component nucleolus nucleus nucleoplasm granular component cytosolic large ribosomal subunit Biological process ribosome biogenesis ribosomal large subunit biogenesis ribosomal small subunit biogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6838 20935 Ensembl ENSG00000148296 ENSG00000281309 ENSMUSG00000036160 UniProt O75683 P70279 RefSeq (mRNA) NM_001278942 NM_006753 NM_009298 RefSeq (protein) NP_001265871 NP_006744 NP_033324 Location (UCSC) Chr 9: 133.33 – 133.34 Mb Chr 2: 26.78 – 26.79 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. The gene demonstrates features of a housekeeping gene, being ubiquitously expressed, and the encoded protein has been localized to the nucleolus. The protein includes motifs found in both the mouse and fish orthologs, which suggests a putative function as a nucleolar-matrix protein with nucleic acid-binding properties, based on characteristics determined in mouse.

Further reading

• Yon J, Jones T, Garson K, et al. (1993). "The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1". Hum. Mol. Genet. 2 (3): 237–40. doi:10.1093/hmg/2.3.237. PMID 8499913.
• Magoulas C, Fried M (1996). "The Surf-6 gene of the mouse surfeit locus encodes a novel nucleolar protein". DNA Cell Biol. 15 (4): 305–16. doi:10.1089/dna.1996.15.305. PMID 8639267.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Magoulas C, Zatsepina OV, Jordan PW, et al. (1998). "The SURF-6 protein is a component of the nucleolar matrix and has a high binding capacity for nucleic acids in vitro". Eur. J. Cell Biol. 75 (2): 174–83. doi:10.1016/s0171-9335(98)80059-9. PMID 9548374.
• Magoulas C, Fried M (2000). "Isolation and genomic analysis of the human surf-6 gene: a member of the Surfeit locus". Gene. 243 (1–2): 115–23. doi:10.1016/S0378-1119(99)00551-X. PMID 10675619.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
• Angiolillo A, Russo G, Porcellini A, et al. (2002). "The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts". Gene. 284 (1–2): 169–78. doi:10.1016/S0378-1119(02)00379-7. PMID 11891058.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.