SNX5

Sorting nexin-5 is a protein that in humans is encoded by the SNX5 gene.

SNX5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1SYS
Identifiers
Aliases	SNX5, sorting nexin 5
External IDs	OMIM: 605937 MGI: 1916428 HomoloGene: 40944 GeneCards: SNX5
Gene location (Human) Chr. Chromosome 20 (human) Band 20p11.23 Start 17,941,597 bp End 17,968,980 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 G1|2 70.98 cM Start 144,092,043 bp End 144,112,826 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left lobe of thyroid gland right lobe of thyroid gland Achilles tendon rectum spleen corpus epididymis secondary oocyte lymph node kidney monocyte Top expressed in abdominal wall dermis maxillary prominence somite endocardial cushion primitive streak atrioventricular valve cervix spleen morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function dynactin binding protein binding phosphatidylinositol binding protein heterodimerization activity lipid binding cadherin binding phosphatidylinositol-5-phosphate binding D1 dopamine receptor binding phosphatidylinositol-4-phosphate binding phosphatidylinositol-3,5-bisphosphate binding Cellular component cytoplasm endosome cell projection early endosome membrane retromer, tubulation complex membrane ruffle extrinsic component of cytoplasmic side of plasma membrane plasma membrane extrinsic component of endosome membrane tubular endosome retromer complex early endosome phagocytic cup cytoplasmic vesicle membrane macropinocytic cup cytoplasmic vesicle cytosol brush border intracellular anatomical structure Biological process endocytosis vesicle organization retrograde transport, endosome to Golgi protein transport pinocytosis intracellular protein transport regulation of macroautophagy epidermal growth factor catabolic process positive regulation of renal sodium excretion negative regulation of blood pressure Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27131 69178 Ensembl ENSG00000089006 ENSMUSG00000027423 UniProt Q9Y5X3 Q5QPE4 Q9D8U8 RefSeq (mRNA) NM_152227 NM_001282454 NM_014426 NM_001199188 NM_024225 RefSeq (protein) NP_001269383 NP_055241 NP_689413 NP_001186117 NP_077187 Location (UCSC) Chr 20: 17.94 – 17.97 Mb Chr 2: 144.09 – 144.11 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein is a component of the mammalian retromer complex, which facilitates cargo retrieval from endosomes to the trans-Golgi network. It has also been shown to bind to the Fanconi anemia, complementation group A protein. This gene results in two transcript variants encoding the same protein.

Interactions

SNX5 has been shown to interact with FANCA.

Further reading

• Maruyama K; Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Teasdale RD, Loci D, Houghton F, et al. (2001). "A large family of endosome-localized proteins related to sorting nexin 1". Biochem. J. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC 1222026. PMID 11485546.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Towler MC, Gleeson PA, Hoshino S, et al. (2005). "Clathrin Isoform CHC22, a Component of Neuromuscular and Myotendinous Junctions, Binds Sorting Nexin 5 and Has Increased Expression during Myogenesis and Muscle Regeneration". Mol. Biol. Cell. 15 (7): 3181–95. doi:10.1091/mbc.E04-03-0249. PMC 452575. PMID 15133132.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Merino-Trigo A, Kerr MC, Houghton F, et al. (2005). "Sorting nexin 5 is localized to a subdomain of the early endosomes and is recruited to the plasma membrane following EGF stimulation". J. Cell Sci. 117 (Pt 26): 6413–24. doi:10.1242/jcs.01561. PMID 15561769. S2CID 39278533.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.