SNAI2

Snail homolog 2 (Drosophila)
Identifiers
Symbols	SNAI2; SLUG; SLUGH1; SNAIL2; WS2D
External IDs	OMIM: 602150 MGI: 1096393 HomoloGene: 31127 GeneCards: SNAI2 Gene
Gene Ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription • chromatin binding • RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity • zinc ion binding • sequence-specific DNA binding Cellular component • nuclear chromatin • nucleus • cytoplasm Biological process • negative regulation of transcription from RNA polymerase II promoter • osteoblast differentiation • epithelial to mesenchymal transition • epithelial to mesenchymal transition involved in endocardial cushion formation • cell migration involved in endocardial cushion formation • negative regulation of cell adhesion involved in substrate-bound cell migration • Notch signaling pathway • sensory perception of sound • embryo development • negative regulation of keratinocyte proliferation • negative regulation of vitamin D biosynthetic process • neural crest cell development • positive regulation of cell migration • negative regulation of chondrocyte differentiation • regulation of chemokine production • negative regulation of cell adhesion mediated by integrin • positive regulation of histone acetylation • negative regulation of catenin import into nucleus • desmosome disassembly • negative regulation of apoptotic process • pigmentation • negative regulation of DNA damage response, signal transduction by p53 class mediator • cellular response to fibroblast growth factor stimulus • positive regulation of fat cell differentiation • regulation of osteoblast differentiation • white fat cell differentiation • palate development • canonical Wnt receptor signaling pathway • epithelium development • cartilage morphogenesis • negative regulation of vitamin D receptor signaling pathway • cellular response to epidermal growth factor stimulus • cellular response to ionizing radiation • negative regulation of canonical Wnt receptor signaling pathway • negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter • negative regulation of stem cell proliferation • regulation of tight junction assembly • negative regulation of anoikis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6591	20583
Ensembl	ENSG00000019549	ENSMUSG00000022676
UniProt	O43623	P97469
RefSeq (mRNA)	NM_003068	NM_011415
RefSeq (protein)	NP_003059	NP_035545
Location (UCSC)	Chr 8: 49.83 – 49.83 Mb	Chr 16: 14.71 – 14.71 Mb
PubMed search	[1]	[2]

Zinc finger protein SNAI2 is a protein that in humans is encoded by the SNAI2 gene.

This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporadic cases of neural tube defects.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Savagner P, Yamada KM, Thiery JP (1997). "The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition.". J. Cell Biol. 137 (6): 1403–19. doi:10.1083/jcb.137.6.1403. PMC 2132541. PMID 9182671. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Stegmann K, Boecker J, Kosan C, et al. (1999). "Human transcription factor SLUG: mutation analysis in patients with neural tube defects and identification of a missense mutation (D119E) in the Slug subfamily-defining region.". Mutat. Res. 406 (2-4): 63–9. doi:10.1016/S1383-5726(99)00002-3. PMID 10479723. 
• Inukai T, Inoue A, Kurosawa H, et al. (1999). "SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein.". Mol. Cell 4 (3): 343–52. doi:10.1016/S1097-2765(00)80336-6. PMID 10518215. 
• Hemavathy K, Guru SC, Harris J, et al. (2000). "Human Slug is a repressor that localizes to sites of active transcription.". Mol. Cell. Biol. 20 (14): 5087–95. doi:10.1128/MCB.20.14.5087-5095.2000. PMC 85958. PMID 10866665. 
• Hajra KM, Chen DY, Fearon ER (2002). "The SLUG zinc-finger protein represses E-cadherin in breast cancer.". Cancer Res. 62 (6): 1613–8. PMID 11912130. 
• Sánchez-Martín M, Rodríguez-García A, Pérez-Losada J, et al. (2003). "SLUG (SNAI2) deletions in patients with Waardenburg disease.". Hum. Mol. Genet. 11 (25): 3231–6. doi:10.1093/hmg/11.25.3231. PMID 12444107. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Kajita M, McClinic KN, Wade PA (2004). "Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress.". Mol. Cell. Biol. 24 (17): 7559–66. doi:10.1128/MCB.24.17.7559-7566.2004. PMC 506998. PMID 15314165. 
• Catalano A, Rodilossi S, Rippo MR, et al. (2004). "Induction of stem cell factor/c-Kit/slug signal transduction in multidrug-resistant malignant mesothelioma cells.". J. Biol. Chem. 279 (45): 46706–14. doi:10.1074/jbc.M406696200. PMID 15337769. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Uchikado Y, Natsugoe S, Okumura H, et al. (2005). "Slug Expression in the E-cadherin preserved tumors is related to prognosis in patients with esophageal squamous cell carcinoma.". Clin. Cancer Res. 11 (3): 1174–80. PMID 15709186. 
• Tripathi MK, Misra S, Khedkar SV, et al. (2005). "Regulation of BRCA2 gene expression by the SLUG repressor protein in human breast cells.". J. Biol. Chem. 280 (17): 17163–71. doi:10.1074/jbc.M501375200. PMID 15734731. 
• Tripathi MK, Misra S, Chaudhuri G (2005). "Negative regulation of the expressions of cytokeratins 8 and 19 by SLUG repressor protein in human breast cells.". Biochem. Biophys. Res. Commun. 329 (2): 508–15. doi:10.1016/j.bbrc.2005.02.006. PMID 15737616. 
• Moody SE, Perez D, Pan TC, et al. (2005). "The transcriptional repressor Snail promotes mammary tumor recurrence.". Cancer Cell 8 (3): 197–209. doi:10.1016/j.ccr.2005.07.009. PMID 16169465. 
• Chen M, Chen LM, Chai KX (2006). "Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG.". Prostate 66 (9): 911–20. doi:10.1002/pros.20325. PMID 16541421. 
• Turner FE, Broad S, Khanim FL, et al. (2006). "Slug regulates integrin expression and cell proliferation in human epidermal keratinocytes.". J. Biol. Chem. 281 (30): 21321–31. doi:10.1074/jbc.M509731200. PMID 16707493.