SMK can refer to:
- Statens Museum for Kunst, the Danish National Gallery
- SMK tank, a Soviet heavy tank prototype
- Slagsmålsklubben, Swedish band
- Smacker video computer video file format
- Super Mario Kart, the debut title in Nintendo's Mario Kart series.
- Sekolah Menengah Kejuruan, an Indonesian type of high school
- Sekolah Menengah Kebangsaan, see types of school in Malaysia
- Strana maďarskej koalície Party of the Hungarian Coalition in Slovakia
- Stowmarket railway station has National Rail code SMK
- Suck My Kiss, a song by the Red Hot Chili Peppers
- Scarecrow and Mrs King
- A type of a coax connector, which is a variant of the SMA connector
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