SCNN1G
| Sodium channel, non-voltage-gated 1, gamma subunit | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | SCNN1G; BESC3; ENaCg; ENaCgamma; PHA1; SCNEG | ||||||||||||
| External IDs | OMIM: 600761 MGI: 104695 HomoloGene: 128649 IUPHAR: ENaC γ ChEMBL: 1628484 GeneCards: SCNN1G Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 6340 | 20278 | |||||||||||
| Ensembl | ENSG00000166828 | ENSMUSG00000000216 | |||||||||||
| UniProt | P51170 | Q9WU39 | |||||||||||
| RefSeq (mRNA) | NM_001039 | NM_011326 | |||||||||||
| RefSeq (protein) | NP_001030 | NP_035456 | |||||||||||
| Location (UCSC) | Chr 16: 23.19 – 23.23 Mb |
Chr 7: 121.73 – 121.77 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Amiloride-sensitive sodium channel subunit gamma is a protein that in humans is encoded by the SCNN1G gene.[1][2]
Interactions
↑Jump back a sectionReferences
- ^ Voilley N, Bassilana F, Mignon C, Merscher S, Mattei MG, Carle GF, Lazdunski M, Barbry P (January 1996). "Cloning, chromosomal localization, and physical linkage of the beta and gamma subunits (SCNN1B and SCNN1G) of the human epithelial amiloride-sensitive sodium channel". Genomics 28 (3): 560–5. doi:10.1006/geno.1995.1188. PMID 7490094.
- ^ "Entrez Gene: SCNN1G sodium channel, nonvoltage-gated 1, gamma".
- ^ Berdiev, Bakhrom K; Jovov Biljana, Tucker Ward C, Naren Anjaparavanda P, Fuller Catherine M, Chapman Edwin R, Benos Dale J (June 2004). "ENaC subunit-subunit interactions and inhibition by syntaxin 1A". Am. J. Physiol. Renal Physiol. (United States) 286 (6): F1100–6. doi:10.1152/ajprenal.00344.2003. ISSN 0363-6127. PMID 14996668.
- ^ Boulkroun, Sheerazed; Ruffieux-Daidié Dorothée, Vitagliano Jean-Jacques, Poirot Olivier, Charles Roch-Philippe, Lagnaz Dagmara, Firsov Dmitri, Kellenberger Stephan, Staub Olivier (October 2008). "Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3". Am. J. Physiol. Renal Physiol. (United States) 295 (4): F889–900. doi:10.1152/ajprenal.00001.2008. ISSN 0363-6127. PMID 18632802.
- ^ Raikwar, Nandita S; Thomas Christie P (May 2008). "Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel". Am. J. Physiol. Renal Physiol. (United States) 294 (5): F1157–65. doi:10.1152/ajprenal.00339.2007. ISSN 0363-6127. PMC 2424110. PMID 18322022.
- ^ Farr, T J; Coddington-Lawson S J, Snyder P M, McDonald F J (February 2000). "Human Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits". Biochem. J. (ENGLAND) 345 (3): 503–9. doi:10.1042/0264-6021:3450503. ISSN 0264-6021. PMC 1220784. PMID 10642508.
- ^ McDonald, Fiona J; Western Andrea H, McNeil John D, Thomas Brittany C, Olson Diane R, Snyder Peter M (September 2002). "Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel". Am. J. Physiol. Renal Physiol. (United States) 283 (3): F431–6. doi:10.1152/ajprenal.00080.2002. ISSN 0363-6127. PMID 12167593.
- ^ Harvey, K F; Dinudom A, Cook D I, Kumar S (March 2001). "The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel". J. Biol. Chem. (United States) 276 (11): 8597–601. doi:10.1074/jbc.C000906200. ISSN 0021-9258. PMID 11244092.
Further reading
- Peters KW, Qi J, Johnson JP, et al. (2002). "Role of snare proteins in CFTR and ENaC trafficking". Pflugers Arch. 443 Suppl 1: S65–9. doi:10.1007/s004240100647. PMID 11845306.
- Waldmann R, Champigny G, Bassilana F, et al. (1996). "Molecular cloning and functional expression of a novel amiloride-sensitive Na+ channel". J. Biol. Chem. 270 (46): 27411–4. doi:10.1074/jbc.270.46.27411. PMID 7499195.
- Hansson JH, Nelson-Williams C, Suzuki H, et al. (1995). "Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome". Nat. Genet. 11 (1): 76–82. doi:10.1038/ng0995-76. PMID 7550319.
- McDonald FJ, Price MP, Snyder PM, Welsh MJ (1995). "Cloning and expression of the beta- and gamma-subunits of the human epithelial sodium channel". Am. J. Physiol. 268 (5 Pt 1): C1157–63. PMID 7762608.
- Snyder PM, Price MP, McDonald FJ, et al. (1996). "Mechanism by which Liddle's syndrome mutations increase activity of a human epithelial Na+ channel". Cell 83 (6): 969–78. doi:10.1016/0092-8674(95)90212-0. PMID 8521520.
- Strautnieks SS, Thompson RJ, Gardiner RM, Chung E (1996). "A novel splice-site mutation in the gamma subunit of the epithelial sodium channel gene in three pseudohypoaldosteronism type 1 families". Nat. Genet. 13 (2): 248–50. doi:10.1038/ng0696-248. PMID 8640238.
- Thomas CP, Doggett NA, Fisher R, Stokes JB (1996). "Genomic organization and the 5' flanking region of the gamma subunit of the human amiloride-sensitive epithelial sodium channel". J. Biol. Chem. 271 (42): 26062–6. doi:10.1074/jbc.271.42.26062. PMID 8824247.
- Firsov D, Schild L, Gautschi I, et al. (1997). "Cell surface expression of the epithelial Na channel and a mutant causing Liddle syndrome: A quantitative approach". Proc. Natl. Acad. Sci. U.S.A. 93 (26): 15370–5. doi:10.1073/pnas.93.26.15370. PMC 26411. PMID 8986818.
- Pirozzi G, McConnell SJ, Uveges AJ, et al. (1997). "Identification of novel human WW domain-containing proteins by cloning of ligand targets". J. Biol. Chem. 272 (23): 14611–6. doi:10.1074/jbc.272.23.14611. PMID 9169421.
- Staub O, Gautschi I, Ishikawa T, et al. (1998). "Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination". EMBO J. 16 (21): 6325–36. doi:10.1093/emboj/16.21.6325. PMC 1170239. PMID 9351815.
- Halushka MK, Fan JB, Bentley K, et al. (1999). "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis". Nat. Genet. 22 (3): 239–47. doi:10.1038/10297. PMID 10391210.
- Arai K, Zachman K, Shibasaki T, Chrousos GP (1999). "Polymorphisms of amiloride-sensitive sodium channel subunits in five sporadic cases of pseudohypoaldosteronism: do they have pathologic potential?". J. Clin. Endocrinol. Metab. 84 (7): 2434–7. doi:10.1210/jc.84.7.2434. PMID 10404817.
- Farr TJ, Coddington-Lawson SJ, Snyder PM, McDonald FJ (2000). "Human Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits". Biochem. J. 345 (3): 503–9. doi:10.1042/0264-6021:3450503. PMC 1220784. PMID 10642508.
- Auerbach SD, Loftus RW, Itani OA, Thomas CP (2000). "Human amiloride-sensitive epithelial Na+ channel gamma subunit promoter: functional analysis and identification of a polypurine-polypyrimidine tract with the potential for triplex DNA formation". Biochem. J. 347 Pt 1 (Pt 1): 105–14. doi:10.1042/0264-6021:3470105. PMC 1220937. PMID 10727408.
- Harvey KF, Dinudom A, Cook DI, Kumar S (2001). "The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel". J. Biol. Chem. 276 (11): 8597–601. doi:10.1074/jbc.C000906200. PMID 11244092.
- Shi H, Asher C, Chigaev A, et al. (2002). "Interactions of beta and gamma ENaC with Nedd4 can be facilitated by an ERK-mediated phosphorylation". J. Biol. Chem. 277 (16): 13539–47. doi:10.1074/jbc.M111717200. PMID 11805112.
- Ottaviani E, Franchini A, Mandrioli M, et al. (2002). "Amiloride-sensitive epithelial sodium channel subunits are expressed in human and mussel immunocytes". Dev. Comp. Immunol. 26 (5): 395–402. doi:10.1016/S0145-305X(01)00097-0. PMID 11906720.
- Saxena A, Hanukoglu I, Saxena D, et al. (2002). "Novel mutations responsible for autosomal recessive multisystem pseudohypoaldosteronism and sequence variants in epithelial sodium channel alpha-, beta-, and gamma-subunit genes". J. Clin. Endocrinol. Metab. 87 (7): 3344–50. doi:10.1210/jc.87.7.3344. PMID 12107247.
External links
- SCNN1G protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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