Sphingosine-1-phosphate receptor 2, also known as S1PR2 or S1P2, is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P).[5]

S1PR2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesS1PR2, AGR16, EDG-5, EDG5, Gpcr13, H218, LPB2, S1P2, DFNB68, sphingosine-1-phosphate receptor 2
External IDsOMIM: 605111 MGI: 99569 HomoloGene: 3118 GeneCards: S1PR2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004230

NM_010333

RefSeq (protein)

NP_004221

NP_034463

Location (UCSC)Chr 19: 10.22 – 10.23 MbChr 9: 20.87 – 20.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function edit

This protein participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation.[5] It has also been shown to interact with Nogo-A (RTN4), an neurite outgrowth inhibitor.[6] S1PR2 is expressed in neuronal and vascular cells and is crucial for the migration and growth of developing and injured neuronal and vascular system.[7] [8]

Evolution edit

Paralogues[9] edit

See also edit

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000267534 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043895 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: S1PR2, sphingosine-1-phosphate receptor 2".
  6. ^ Kempf A, Tews B, Arzt ME, Weinmann O, Obermair FJ, Pernet V, Zagrebelsky M, Delekate A, Iobbi C, Zemmar A, Ristic Z, Gullo M, Spies P, Dodd D, Gygax D, Korte M, Schwab ME, Schiavo G (14 January 2014). "The Sphingolipid Receptor S1PR2 Is a Receptor for Nogo-A Repressing Synaptic Plasticity". PLOS Biology. 12 (1): e1001763. doi:10.1371/journal.pbio.1001763. PMC 3891622. PMID 24453941.
  7. ^ Rust R, Grönnert L, Gantner C, Enzler A, Mulders G, Weber RZ, Siewert A, Limasale YDP, Meinhardt A, Maurer MA, Sartori AM, Hofer AS, Werner C, Schwab ME (9 July 2019). "Nogo-A targeted therapy promotes vascular repair and functional recovery following stroke". Proceedings of the National Academy of Sciences. 116 (28): 14270–14279. Bibcode:2019PNAS..11614270R. doi:10.1073/pnas.1905309116. PMC 6628809. PMID 31235580.
  8. ^ Rust R, Grönnert L, Weber RZ, Mulders G, Schwab ME (September 2019). "Refueling the Ischemic CNS: Guidance Molecules for Vascular Repair". Trends in Neurosciences. 42 (9): 644–656. doi:10.1016/j.tins.2019.05.006. PMID 31285047. S2CID 195834057.
  9. ^ "GeneCards®: The Human Gene Database".

Further reading edit

External links edit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.