RTN2

Reticulon-2 is a protein that in humans is encoded by the RTN2 gene.

RTN2
Identifiers
Aliases	RTN2, NSP2, NSPL1, NSPLI, SPG12, reticulon 2
External IDs	OMIM: 603183 MGI: 107612 HomoloGene: 32180 GeneCards: RTN2
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.32 Start 45,485,294 bp End 45,497,055 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 A3|7 9.54 cM Start 19,016,549 bp End 19,030,085 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle vastus lateralis muscle thoracic diaphragm triceps brachii muscle biceps brachii body of tongue deltoid muscle tibialis anterior muscle Brodmann area 10 spinal ganglia Top expressed in triceps brachii muscle temporal muscle sternocleidomastoid muscle ankle digastric muscle extensor digitorum longus muscle vastus lateralis muscle tibialis anterior muscle soleus muscle plantaris muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane T-tubule integral component of endoplasmic reticulum membrane endoplasmic reticulum membrane endoplasmic reticulum membrane terminal cisterna Biological process intracellular protein transmembrane transport regulation of glucose import Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6253 20167 Ensembl ENSG00000125744 ENSMUSG00000030401 UniProt O75298 Q96CG9 O70622 RefSeq (mRNA) NM_206902 NM_005619 NM_206900 NM_206901 NM_001025364 NM_013648 RefSeq (protein) NP_005610 NP_996783 NP_996784 NP_001020535 NP_038676 Location (UCSC) Chr 19: 45.49 – 45.5 Mb Chr 7: 19.02 – 19.03 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. Alternatively spliced transcript variants encoding different isoforms have been identified.

Further reading

• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• He W, Lu Y, Qahwash I, et al. (2004). "Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation". Nat. Med. 10 (9): 959–65. doi:10.1038/nm1088. PMID 15286784. S2CID 23570406.
• Reuter TY, Medhurst AL, Waisfisz Q, et al. (2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Exp. Cell Res. 289 (2): 211–21. doi:10.1016/S0014-4827(03)00261-1. PMID 14499622.
• Oertle T, Klinger M, Stuermer CA, Schwab ME (2003). "A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family". FASEB J. 17 (10): 1238–47. doi:10.1096/fj.02-1166hyp. PMID 12832288. S2CID 27903.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Geisler JG, Palmer RJ, Stubbs LJ, Mucenski ML (2000). "Nspl1, a new Z-band-associated protein". J. Muscle Res. Cell. Motil. 20 (7): 661–8. doi:10.1023/A:1005533013926. PMID 10672514. S2CID 26327921.
• Roebroek AJ, Contreras B, Pauli IG, Van de Ven WJ (1998). "cDNA cloning, genomic organization, and expression of the human RTN2 gene, a member of a gene family encoding reticulons". Genomics. 51 (1): 98–106. doi:10.1006/geno.1997.5175. PMID 9693037.