RECK

Reversion-inducing-cysteine-rich protein with kazal motifs, also known as RECK, is a human gene, thought to be a metastasis suppressor.

RECK
Identifiers
Aliases	RECK, ST15, reversion inducing cysteine rich protein with kazal motifs
External IDs	OMIM: 605227 MGI: 1855698 HomoloGene: 9622 GeneCards: RECK
Gene location (Human) Chr. Chromosome 9 (human) Band 9p13.3 Start 36,036,913 bp End 36,124,455 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 B1 Start 43,875,530 bp End 43,944,806 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parietal pleura germinal epithelium tibia stromal cell of endometrium visceral pleura lactiferous duct synovial joint Achilles tendon pericardium lower lobe of lung Top expressed in iris dermis calvaria left lung lobe vas deferens sciatic nerve ciliary body belly cord abdominal wall molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metalloendopeptidase inhibitor activity peptidase inhibitor activity endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity Wnt-protein binding coreceptor activity involved in canonical Wnt signaling pathway Cellular component anchored component of membrane membrane extracellular region plasma membrane Wnt signalosome Biological process vasculature development regulation of canonical Wnt signaling pathway negative regulation of metalloendopeptidase activity negative regulation of peptidase activity negative regulation of cell migration embryonic forelimb morphogenesis embryo implantation blood vessel maturation extracellular matrix organization sprouting angiogenesis Wnt signaling pathway regulation of angiogenesis canonical Wnt signaling pathway regulation of establishment of blood-brain barrier positive regulation of canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8434 53614 Ensembl ENSG00000122707 ENSMUSG00000028476 UniProt O95980 Q9Z0J1 RefSeq (mRNA) NM_001316345 NM_001316346 NM_001316347 NM_001316348 NM_021111 NM_016678 RefSeq (protein) NP_001303275.1 NP_001303276.1 NP_001303277.1 NP_001303274 NP_001303275 NP_001303276 NP_001303277 NP_066934 NP_057887 Location (UCSC) Chr 9: 36.04 – 36.12 Mb Chr 4: 43.88 – 43.94 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

For the surname, see Reck.

The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. It is one of the targets of an oncomiR, MIRN21.

Further reading

• Takahashi C, Sheng Z, Horan TP, et al. (1998). "Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK". Proc. Natl. Acad. Sci. U.S.A. 95 (22): 13221–6. Bibcode:1998PNAS...9513221T. doi:10.1073/pnas.95.22.13221. PMC 23764. PMID 9789069.
• Gerstein M (1998). "Measurement of the effectiveness of transitive sequence comparison, through a third 'intermediate' sequence". Bioinformatics. 14 (8): 707–14. doi:10.1093/bioinformatics/14.8.707. PMID 9789096.
• Oh J, Takahashi R, Kondo S, et al. (2002). "The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis". Cell. 107 (6): 789–800. doi:10.1016/S0092-8674(01)00597-9. hdl:2433/149674. PMID 11747814.
• Eisenberg I, Hochner H, Sadeh M, et al. (2003). "Establishment of the genomic structure and identification of thirteen single-nucleotide polymorphisms in the human RECK gene". Cytogenet. Genome Res. 97 (1–2): 58–61. doi:10.1159/000064042. PMID 12438739. S2CID 27366060.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Masui T, Doi R, Koshiba T, et al. (2004). "RECK expression in pancreatic cancer: its correlation with lower invasiveness and better prognosis". Clin. Cancer Res. 9 (5): 1779–84. PMID 12738734.
• Liu LT, Chang HC, Chiang LC, Hung WC (2003). "Histone deacetylase inhibitor up-regulates RECK to inhibit MMP-2 activation and cancer cell invasion". Cancer Res. 63 (12): 3069–72. PMID 12810630.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Takeuchi T, Hisanaga M, Nagao M, et al. (2005). "The membrane-anchored matrix metalloproteinase (MMP) regulator RECK in combination with MMP-9 serves as an informative prognostic indicator for colorectal cancer". Clin. Cancer Res. 10 (16): 5572–9. doi:10.1158/1078-0432.CCR-03-0656. PMID 15328199.
• Simizu S, Takagi S, Tamura Y, Osada H (2005). "RECK-mediated suppression of tumor cell invasion is regulated by glycosylation in human tumor cell lines". Cancer Res. 65 (16): 7455–61. doi:10.1158/0008-5472.CAN-04-4446. PMID 16103099.
• Hsu MC, Chang HC, Hung WC (2006). "HER-2/neu represses the metastasis suppressor RECK via ERK and Sp transcription factors to promote cell invasion". J. Biol. Chem. 281 (8): 4718–25. doi:10.1074/jbc.M510937200. PMID 16377629.
• Correa TC, Brohem CA, Winnischofer SM, et al. (2006). "Downregulation of the RECK-tumor and metastasis suppressor gene in glioma invasiveness". J. Cell. Biochem. 99 (1): 156–67. doi:10.1002/jcb.20917. PMID 16791855. S2CID 24574103.
• Chang HC, Cho CY, Hung WC (2007). "Silencing of the metastasis suppressor RECK by RAS oncogene is mediated by DNA methyltransferase 3b-induced promoter methylation". Cancer Res. 66 (17): 8413–20. doi:10.1158/0008-5472.CAN-06-0685. PMID 16951151.
• Lei H, Hemminki K, Altieri A, et al. (2007). "Promoter polymorphisms in matrix metalloproteinases and their inhibitors: few associations with breast cancer susceptibility and progression". Breast Cancer Res. Treat. 103 (1): 61–9. doi:10.1007/s10549-006-9345-2. PMID 17033924. S2CID 5750512.
• Chang HC, Cho CY, Hung WC (2007). "Downregulation of RECK by promoter methylation correlates with lymph node metastasis in non-small cell lung cancer". Cancer Sci. 98 (2): 169–73. doi:10.1111/j.1349-7006.2006.00367.x. PMID 17233834. S2CID 25904319.
• Kang HG, Kim HS, Kim KJ, et al. (2007). "RECK expression in osteosarcoma: correlation with matrix metalloproteinases activation and tumor invasiveness". J. Orthop. Res. 25 (5): 696–702. doi:10.1002/jor.20323. PMID 17262820. S2CID 26447647.
• Mori T, Moriuchi R, Okazaki E, et al. (2007). "Tgat oncoprotein functions as an inhibitor of RECK by association of the unique C-terminal region". Biochem. Biophys. Res. Commun. 355 (4): 937–43. doi:10.1016/j.bbrc.2007.02.051. PMID 17328864.
• Miki T, Takegami Y, Okawa K, et al. (2007). "The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) interacts with membrane type 1 matrix metalloproteinase and CD13/aminopeptidase N and modulates their endocytic pathways". J. Biol. Chem. 282 (16): 12341–52. doi:10.1074/jbc.M610948200. PMID 17329256.
• Cho CY, Wang JH, Chang HC, et al. (2007). "Epigenetic inactivation of the metastasis suppressor RECK enhances invasion of human colon cancer cells". J. Cell. Physiol. 213 (1): 65–9. doi:10.1002/jcp.21089. PMID 17443689. S2CID 23582775.