CAAX prenyl protease 2 is an enzyme that in humans is encoded by the RCE1 gene .[5] [6] [7]
This gene encodes an integral membrane protein which is classified as a member of the metalloproteinase family. This enzyme is thought to function in the maintenance and processing of CAAX-type prenylated proteins.[7]
References
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^ a b c GRCh38: Ensembl release 89: ENSG00000173653 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024889 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Otto JC, Kim E, Young SG, Casey PJ (Apr 1999). "Cloning and characterization of a mammalian prenyl protein-specific protease" . J Biol Chem . 274 (13): 8379–82. doi :10.1074/jbc.274.13.8379 PMID 10085068 . ^ Freije JM, Blay P, Pendas AM, Cadinanos J, Crespo P, Lopez-Otin C (Jul 1999). "Identification and chromosomal location of two human genes encoding enzymes potentially involved in proteolytic maturation of farnesylated proteins". Genomics . 58 (3): 270–80. doi :10.1006/geno.1999.5834 . PMID 10373325 . ^ a b "Entrez Gene: RCE1 RCE1 homolog, prenyl protein peptidase (S. cerevisiae)" .
Further reading
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Plummer LJ, Hildebrandt ER, Porter SB, et al. (2006). "Mutational Analysis of the Ras Converting Enzyme Reveals a Requirement for Glutamate and Histidine Residues" . J. Biol. Chem . 281 (8): 4596–605. doi :10.1074/jbc.M506284200 PMC 2937830 PMID 16361710 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Bergo MO, Lieu HD, Gavino BJ, et al. (2004). "On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy" . J. Biol. Chem . 279 (6): 4729–36. doi :10.1074/jbc.M310081200 PMID 14625273 . Maske CP, Hollinshead MS, Higbee NC, et al. (2003). "A carboxyl-terminal interaction of lamin B1 is dependent on the CAAX endoprotease Rce1 and carboxymethylation" . J. Cell Biol . 162 (7): 1223–32. doi :10.1083/jcb.200303113 . PMC 2173957 PMID 14504265 . Hollander IJ, Frommer E, Aulabaugh A, Mallon R (2003). "Human Ras converting enzyme endoproteolytic specificity at the P2' and P3' positions of K-Ras-derived peptides". Biochim. Biophys. Acta . 1649 (1): 24–9. doi :10.1016/s1570-9639(03)00150-x . PMID 12818187 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Hollander I, Frommer E, Mallon R (2000). "Human ras-converting enzyme (hRCE1) endoproteolytic activity on K-ras-derived peptides". Anal. Biochem . 286 (1): 129–37. doi :10.1006/abio.2000.4795 . PMID 11038283 .
