RBM7

RNA-binding motif protein 7 is a protein that in humans is encoded by the RBM7 gene.

RBM7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2M8H, 5IQQ
Identifiers
Aliases	RBM7, RNA binding motif protein 7
External IDs	OMIM: 612413 MGI: 1914260 HomoloGene: 9379 GeneCards: RBM7
Gene location (Human) Chr. Chromosome 11 (human) Band 11q23.2 Start 114,400,030 bp End 114,414,203 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A5.3 Start 48,400,001 bp End 48,406,599 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon germinal epithelium stromal cell of endometrium islet of Langerhans rectum caput epididymis gallbladder palpebral conjunctiva corpus epididymis endothelial cell Top expressed in seminal vesicula medial ganglionic eminence lacrimal gland left lung lobe olfactory epithelium conjunctival fornix sciatic nerve hair follicle interventricular septum parotid gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleic acid binding single-stranded RNA binding RNA binding protein binding Cellular component nucleoplasm nucleolus nucleus Biological process meiosis regulation of alternative mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10179 67010 Ensembl ENSG00000076053 ENSMUSG00000042396 UniProt Q9Y580 Q9CQT2 RefSeq (mRNA) NM_016090 NM_001286045 NM_001286046 NM_001286047 NM_001286048 NM_144948 NM_001326355 NM_001326356 RefSeq (protein) NP_001272974 NP_001272975 NP_001272976 NP_001272977 NP_057174 NP_001313284 NP_001313285 NP_659197 Location (UCSC) Chr 11: 114.4 – 114.41 Mb Chr 9: 48.4 – 48.41 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

RBM7 has been shown to interact with SF3B2 and SFRS3.

Further reading

• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Guo TB, Boros LG, Chan KC, Hikim AP, Hudson AP, Swerdloff RS, Mitchell AP, Salameh WA (2003). "Spermatogenetic expression of RNA-binding motif protein 7, a protein that interacts with splicing factors". Journal of Andrology. 24 (2): 204–14. doi:10.1002/j.1939-4640.2003.tb02664.x. PMID 12634307.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Bugai A, Quaresma AJ, Friedel CC (Apr 2019). "P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress". Molecular Cell. 74 (2): 254–267.e10. doi:10.1016/j.molcel.2019.01.033. PMC 6482433. PMID 30824372.
• Fukushima K, Satoh T, Sugihara F (Mar 2020). "Dysregulated Expression of the Nuclear Exosome Targeting Complex Component Rbm7 in Nonhematopoietic Cells Licenses the Development of Fibrosis". Immunity. 52 (3): 542–556.e13. doi:10.1016/j.immuni.2020.02.007. PMID 32187520. Rbm7 in epithelial cells plays a critical role in the development of fibrosis by regulating ncRNA decay and thereby the production of chemokines.

External links

• RBM7 human gene location in the UCSC Genome Browser.
• RBM7 human gene details in the UCSC Genome Browser.