Ras association domain-containing protein 5 is a protein that in humans is encoded by the RASSF5 or F5 gene.[5][6][7]

RASSF5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRASSF5, Maxp1, NORE1, NORE1A, NORE1B, RAPL, RASSF3, Ras association domain family member 5
External IDsOMIM: 607020 MGI: 1926375 HomoloGene: 10296 GeneCards: RASSF5
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_182665
NM_031437
NM_182663
NM_182664

NM_018750
NM_001311094
NM_001313731

RefSeq (protein)

NP_872604
NP_872605
NP_872606

NP_001298023
NP_001300660
NP_061220

Location (UCSC)Chr 1: 206.51 – 206.59 MbChr 1: 131.1 – 131.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function edit

This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene.[7]

Interactions edit

RASSF5 has been shown to interact with RRAS,[8] RAP2A,[8] MRAS[8] and RASSF1.[8]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000266094 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026430 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yao R, Wang Y, You M (Apr 2002). "Chromosome mapping and sequence variation of the murine Ras effector gene Nore1". Cytogenetics and Cell Genetics. 95 (1–2): 126–8. doi:10.1159/000057035. PMID 11978988. S2CID 26933977.
  6. ^ Tommasi S, Dammann R, Jin SG, Zhang XF, Avruch J, Pfeifer GP (Apr 2002). "RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1". Oncogene. 21 (17): 2713–20. doi:10.1038/sj.onc.1205365. PMID 11965544.
  7. ^ a b "Entrez Gene: RASSF5 Ras association (RalGDS/AF-6) domain family 5".
  8. ^ a b c d Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J (Feb 2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene. 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. PMID 11857081.

Further reading edit