Pequea is a variation of the Shawnee Pekowi.
Pequea may also refer to the following in Pennsylvania:
- Pequea Bridge (disambiguation)
- Pequea Creek, a tributary of the Susquehanna River
- Pequea, Pennsylvania, an unincorporated community in Martic Township in Lancaster County
- Pequea Township, Lancaster County, Pennsylvania
- Pequea Valley School District, in Lancaster County
- Pequea Valley High School, in the above district
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