PTPRO

Receptor-type tyrosine-protein phosphatase O is an enzyme that in humans is encoded by the PTPRO gene.

PTPRO
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2G59, 2GJT
Identifiers
Aliases	PTPRO, GLEPP1, NPHS6, PTP-OC, PTP-U2, PTPROT, PTPU2, R-PTP-O, protein tyrosine phosphatase, receptor type O, protein tyrosine phosphatase receptor type O
External IDs	OMIM: 600579 MGI: 1097152 HomoloGene: 21564 GeneCards: PTPRO
Gene location (Human) Chr. Chromosome 12 (human) Band 12p12.3|12p13-p12 Start 15,322,257 bp End 15,602,175 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 G1 Start 137,229,317 bp End 137,440,231 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in glomerulus metanephric glomerulus rectum ganglionic eminence middle temporal gyrus kidney nucleus accumbens prefrontal cortex monocyte Brodmann area 46 Top expressed in renal corpuscle arcuate nucleus median eminence olfactory bulb barrel cortex ventromedial nucleus piriform cortex mammillary body dorsomedial hypothalamic nucleus substantia nigra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoprotein phosphatase activity protein homodimerization activity phosphatase activity Wnt-protein binding protein binding protein tyrosine phosphatase activity transmembrane receptor protein tyrosine phosphatase activity hydrolase activity Cellular component integral component of membrane lateral plasma membrane membrane growth cone plasma membrane dendritic spine integral component of plasma membrane axon apical plasma membrane neuron projection extracellular exosome lamellipodium glutamatergic synapse GABA-ergic synapse integral component of postsynaptic density membrane Biological process negative regulation of cell-substrate adhesion negative regulation of neuron projection development monocyte chemotaxis negative regulation of retinal ganglion cell axon guidance regulation of glomerular filtration slit diaphragm assembly protein dephosphorylation glomerulus development axon guidance cell morphogenesis glomerular visceral epithelial cell differentiation peptidyl-tyrosine dephosphorylation negative regulation of glomerular filtration negative regulation of canonical Wnt signaling pathway lamellipodium assembly dephosphorylation regulation of synapse organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5800 19277 Ensembl ENSG00000151490 ENSMUSG00000030223 UniProt Q16827 E9Q612 RefSeq (mRNA) NM_002848 NM_030667 NM_030668 NM_030669 NM_030670 NM_030671 NM_001164401 NM_001164402 NM_001164403 NM_011216 RefSeq (protein) NP_002839 NP_109592 NP_109593 NP_109594 NP_109595 NP_109596 NP_001157873 NP_001157874 NP_001157875 NP_035346 Location (UCSC) Chr 12: 15.32 – 15.6 Mb Chr 6: 137.23 – 137.44 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a receptor-type protein tyrosine phosphatase containing a single intracellular catalytic domain with a characteristic signature motif. The gene product, which has a transmembrane domain, is an integral membrane protein. Several alternatively spliced transcript variants, some of which encode different isoforms of the protein, have been described. These variants exhibit tissue-specific expression.

Further reading

• Seimiya H, Sawabe T, Inazawa J, Tsuruo T (1995). "Cloning, expression and chromosomal localization of a novel gene for protein tyrosine phosphatase (PTP-U2) induced by various differentiation-inducing agents". Oncogene. 10 (9): 1731–8. PMID 7753550.
• Feito MJ, Bragardo M, Buonfiglio D, Bonissoni S, Bottarel F, Malavasi F, Dianzani U (1997). "gp 120s derived from four syncytium-inducing HIV-1 strains induce different patterns of CD4 association with lymphocyte surface molecules". Int. Immunol. 9 (8): 1141–7. doi:10.1093/intimm/9.8.1141. PMID 9263011.
• Avraham S, London R, Tulloch GA, Ellis M, Fu Y, Jiang S, White RA, Painter C, Steinberger A (1998). "Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells". Gene. 204 (1–2): 5–16. doi:10.1016/S0378-1119(97)00420-4. PMID 9434160.
• Taniguchi Y, London R, Schinkmann K, Jiang S, Avraham H (1999). "The receptor protein tyrosine phosphatase, PTP-RO, is upregulated during megakaryocyte differentiation and Is associated with the c-Kit receptor". Blood. 94 (2): 539–49. doi:10.1182/blood.V94.2.539. PMID 10397721.
• Aguiar RC, Yakushijin Y, Kharbanda S, Tiwari S, Freeman GJ, Shipp MA (1999). "PTPROt: an alternatively spliced and developmentally regulated B-lymphoid phosphatase that promotes G0/G1 arrest". Blood. 94 (7): 2403–13. doi:10.1182/blood.V94.7.2403.419k39_2403_2413. PMID 10498613. S2CID 15259010.
• Wang Z, Bhattacharya N, Meyer MK, Seimiya H, Tsuruo T, Tonani JA, Magnuson NS (2001). "Pim-1 negatively regulates the activity of PTP-U2S phosphatase and influences terminal differentiation and apoptosis of monoblastoid leukemia cells". Arch. Biochem. Biophys. 390 (1): 9–18. doi:10.1006/abbi.2001.2370. PMID 11368509.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Motiwala T, Kutay H, Ghoshal K, Bai S, Seimiya H, Tsuruo T, Suster S, Morrison C, Jacob ST (2004). "Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer". Proc. Natl. Acad. Sci. U.S.A. 101 (38): 13844–9. Bibcode:2004PNAS..10113844M. doi:10.1073/pnas.0405451101. PMC 518843. PMID 15356345.
• Chen L, Juszczynski P, Takeyama K, Aguiar RC, Shipp MA (2007). "Protein tyrosine phosphatase receptor-type O truncated (PTPROt) regulates SYK phosphorylation, proximal B-cell-receptor signaling, and cellular proliferation". Blood. 108 (10): 3428–33. doi:10.1182/blood-2006-03-013821. PMID 16888096.
• Motiwala T, Majumder S, Kutay H, Smith DS, Neuberg DS, Lucas DM, Byrd JC, Grever M, Jacob ST (2007). "Methylation and Silencing of Protein Tyrosine Phosphatase Receptor Type O in Chronic Lymphocytic Leukemia". Clin. Cancer Res. 13 (11): 3174–81. doi:10.1158/1078-0432.CCR-06-1720. PMC 3074612. PMID 17545520.
• Tian J, Wang HP, Mao YY, Jin J, Chen JH (2007). "Reduced glomerular epithelial protein 1 expression and podocyte injury in immunoglobulin A nephropathy". J. Int. Med. Res. 35 (3): 338–45. doi:10.1177/147323000703500308. PMID 17593862. S2CID 24500200.