PSCDBP

CYTIP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2Z17
Identifiers
Aliases	CYTIP, B3-1, CASP, CYBR, CYTHIP, HE, PSCDBP, cytohesin 1 interacting protein
External IDs	OMIM: 604448 MGI: 2183535 HomoloGene: 3167 GeneCards: CYTIP
Gene location (Human)
Chr.	Chromosome 2 (human)
End	157,488,961 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	58,085,544 bp
RNA expression pattern
	Top expressed in
	blood; ; bone marrow cells; ; monocyte; ; appendix; ; lymph node; ; spleen; ; thymus; ; jejunal mucosa; ; periodontal fiber; ; right lung;
	Top expressed in
	spleen; ; right lung lobe; ; thymus; ; blood; ; bone marrow; ; Paneth cell; ; left lung; ; submandibular gland; ; left lung lobe; ; subcutaneous adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; endosome; cell cortex; early endosome; nucleoplasm; cytosol;
Biological process	regulation of cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	9595
	227929
	ENSG00000115165
	ENSMUSG00000026832
	O60759
	Q91VY6
	NM_004288
	NM_139200
	NP_004279
	NP_631939
	Wikidata
View/Edit Human	View/Edit Mouse

Cytohesin-interacting protein is a protein that in humans is encoded by the CYTIP gene.^[5]^[6]^[7]^[8]

The protein encoded by this gene contains 2 leucine zipper domains and a putative C-terminal nuclear targeting signal, and it does not have any hydrophobic regions. This protein is expressed weakly in resting NK and T cells.^[8]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115165 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026832 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dixon B, Sahely B, Liu L, Pohajdak B (Jan 1994). "Cloning a cDNA from human NK/T cells which codes for an unusual leucine zipper containing protein". Biochim Biophys Acta. 1216 (2): 321–4. doi:10.1016/0167-4781(93)90165-a. PMID 8241278.
^ Kim HS (Jun 1999). "Assignment of the human B3-1 gene (PSCDBP) to chromosome 2 band q11.2 by radiation hybrid mapping". Cytogenet Cell Genet. 84 (1–2): 95. doi:10.1159/000015226. PMID 10343115. S2CID 7420858.
^ Tang P, Cheng TP, Agnello D, Wu CY, Hissong BD, Watford WT, Ahn HJ, Galon J, Moss J, Vaughan M, O'Shea JJ, Gadina M (Mar 2002). "Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity". Proc Natl Acad Sci USA. 99 (5): 2625–9. Bibcode:2002PNAS...99.2625T. doi:10.1073/pnas.052712999. PMC 122398. PMID 11867758.
^ ^a ^b "Entrez Gene: PSCDBP pleckstrin homology, Sec7 and coiled-coil domains, binding protein".

Further reading edit

Mansour M, Lee SY, Pohajdak B (2002). "The N-terminal coiled coil domain of the cytohesin/ARNO family of guanine nucleotide exchange factors interacts with the scaffolding protein CASP". J. Biol. Chem. 277 (35): 32302–9. doi:10.1074/jbc.M202898200. PMID 12052827.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Boehm T, Hofer S, Winklehner P, et al. (2003). "Attenuation of cell adhesion in lymphocytes is regulated by CYTIP, a protein which mediates signal complex sequestration". EMBO J. 22 (5): 1014–24. doi:10.1093/emboj/cdg101. PMC 150334. PMID 12606567.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
Chen Q, Coffey A, Bourgoin SG, Gadina M (2006). "Cytohesin binder and regulator augments T cell receptor-induced nuclear factor of activated T Cells.AP-1 activation through regulation of the JNK pathway". J. Biol. Chem. 281 (29): 19985–94. doi:10.1074/jbc.M601629200. PMID 16702224.
MacNeil AJ, Mansour M, Pohajdak B (2007). "Sorting nexin 27 interacts with the Cytohesin associated scaffolding protein (CASP) in lymphocytes". Biochem. Biophys. Res. Commun. 359 (4): 848–53. doi:10.1016/j.bbrc.2007.05.162. PMID 17577583.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115165 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026832 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8241278-5] Dixon B, Sahely B, Liu L, Pohajdak B (Jan 1994). "Cloning a cDNA from human NK/T cells which codes for an unusual leucine zipper containing protein". Biochim Biophys Acta. 1216 (2): 321–4. doi:10.1016/0167-4781(93)90165-a. PMID 8241278.

[pmid10343115-6] Kim HS (Jun 1999). "Assignment of the human B3-1 gene (PSCDBP) to chromosome 2 band q11.2 by radiation hybrid mapping". Cytogenet Cell Genet. 84 (1–2): 95. doi:10.1159/000015226. PMID 10343115. S2CID 7420858.

[pmid11867758-7] Tang P, Cheng TP, Agnello D, Wu CY, Hissong BD, Watford WT, Ahn HJ, Galon J, Moss J, Vaughan M, O'Shea JJ, Gadina M (Mar 2002). "Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity". Proc Natl Acad Sci USA. 99 (5): 2625–9. Bibcode:2002PNAS...99.2625T. doi:10.1073/pnas.052712999. PMC 122398. PMID 11867758.

[entrez-8] "Entrez Gene: PSCDBP pleckstrin homology, Sec7 and coiled-coil domains, binding protein".

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