PIK3R5

Phosphoinositide 3-kinase regulatory subunit 5 is an enzyme that in humans is encoded by the PIK3R5 gene.

PIK3R5
Identifiers
Aliases	PIK3R5, F730038I15Rik, FOAP-2, P101-PI3K, p101, phosphoinositide-3-kinase regulatory subunit 5
External IDs	OMIM: 611317 MGI: 2443588 HomoloGene: 8627 GeneCards: PIK3R5
Gene location (Human) Chr. Chromosome 17 (human) Band 17p13.1 Start 8,878,911 bp End 8,965,712 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 B3 Start 68,322,947 bp End 68,388,675 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood monocyte spleen bone marrow cells upper lobe of left lung lymph node right lung appendix gallbladder spongy bone Top expressed in thymus blood spleen outer nuclear layer subcutaneous adipose tissue calvaria facial motor nucleus inner nuclear layer jejunum right lung More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G-protein beta/gamma-subunit complex binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity 1-phosphatidylinositol-3-kinase regulator activity Cellular component cytoplasm plasma membrane phosphatidylinositol 3-kinase complex, class IB membrane nucleus phosphatidylinositol 3-kinase complex microtubule organizing center cytosol Biological process platelet activation positive regulation of protein kinase B signaling regulation of phosphatidylinositol 3-kinase activity positive regulation of MAP kinase activity phosphatidylinositol 3-kinase signaling phosphatidylinositol phosphate biosynthetic process G protein-coupled receptor signaling pathway positive regulation of phosphatidylinositol 3-kinase signaling phosphatidylinositol biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23533 320207 Ensembl ENSG00000141506 ENSMUSG00000020901 UniProt Q8WYR1 Q5SW28 RefSeq (mRNA) NM_001142633 NM_001251851 NM_001251852 NM_001251853 NM_001251855 NM_014308 NM_001388396 NM_001388397 NM_001388398 NM_001388399 NM_001388400 NM_177320 RefSeq (protein) NP_001136105 NP_001238780 NP_001238781 NP_001238782 NP_001238784 NP_055123 NP_796294.2 NP_796294 Location (UCSC) Chr 17: 8.88 – 8.97 Mb Chr 11: 68.32 – 68.39 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

PIK3R5 has been shown to interact with PIK3CG.

Further reading

• Johnson C, Marriott SJ, Levy LS (2007). "Overexpression of p101 activates PI3Kgamma signaling in T cells and contributes to cell survival". Oncogene. 26 (49): 7049–57. doi:10.1038/sj.onc.1210504. PMID 17486067.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Suire S, Coadwell J, Ferguson GJ, et al. (2005). "p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma". Curr. Biol. 15 (6): 566–70. Bibcode:2005CBio...15..566S. doi:10.1016/j.cub.2005.02.020. PMID 15797027. S2CID 12255918.
• Voigt P, Brock C, Nürnberg B, et al. (2005). "Assigning functional domains within the p101 regulatory subunit of phosphoinositide 3-kinase gamma". J. Biol. Chem. 280 (6): 5121–7. doi:10.1074/jbc.M413104200. PMID 15611065.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Metjian A, Roll RL, Ma AD, et al. (1999). "Agonists cause nuclear translocation of phosphatidylinositol 3-kinase gamma. A Gbetagamma-dependent pathway that requires the p110gamma amino terminus". J. Biol. Chem. 274 (39): 27943–7. doi:10.1074/jbc.274.39.27943. PMID 10488142.
• Krugmann S, Hawkins PT, Pryer N, et al. (1999). "Characterizing the interactions between the two subunits of the p101/p110gamma phosphoinositide 3-kinase and their role in the activation of this enzyme by G beta gamma subunits". J. Biol. Chem. 274 (24): 17152–8. doi:10.1074/jbc.274.24.17152. PMID 10358071.