P/D1 cells are cells lining the fundus of the human stomach that produce ghrelin. Removal of these cells in gastric bypass surgery has a profound impact on later appetite regulation.[1] These cells have also been shown to produce ghrelin's antagonistic hormone leptin.[2] PD/1 cells are equivalent to A-like cells in rats and X-type cells in dogs. These endocrine cells can be microscopically distinguished from other gastric endocrine cells through their round, compact, electron-dense secretory granules.[3]
References edit
- ^ Inui A, Asakawa A, Bowers CY, et al. (2004). "Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ". FASEB J. 18 (3): 439–56. doi:10.1096/fj.03-0641rev. PMID 15003990. S2CID 15642270.
- ^ Bado A, Levasseur S, Attoub S, Kermorgant S, Laigneau JP, Bortoluzzi MN, Moizo L, Lehy T, Guerre-Millo M, Le Marchand-Brustel Y, Lewin MJ (1998). "The stomach is a source of leptin". Nature. 394 (6695): 790–793. Bibcode:1998Natur.394..790B. doi:10.1038/29547. PMID 9723619. S2CID 4367948.
- ^ Sakata, Ichiro; Sakai, Takafumi (14 March 2010). "Ghrelin Cells in the Gastrointestinal Tract". International Journal of Peptides. 2010: 1–7. doi:10.1155/2010/945056. PMC 2925405. PMID 20798855.
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