Oxysterol-binding protein-related protein 5 is a protein that in humans is encoded by the OSBPL5 gene .[5]
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Transcript variants encoding different isoforms have been identified.[5]
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Further reading
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Laitinen S, Olkkonen VM, Ehnholm C, Ikonen E (2000). "Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism" . J. Lipid Res . 40 (12): 2204–11. doi :10.1016/S0022-2275(20)32095-2 PMID 10588946 . Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 7 (2): 143–50. doi :10.1093/dnares/7.2.143 PMID 10819331 . Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination" . Genome Res . 10 (11): 1788–95. doi :10.1101/gr.143000 . PMC 310948 PMID 11076863 . Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs" . Genome Res . 11 (3): 422–35. doi :10.1101/gr.GR1547R . PMC 311072 PMID 11230166 . Lehto M, Laitinen S, Chinetti G, et al. (2001). "The OSBP-related protein family in humans" . J. Lipid Res . 42 (8): 1203–13. doi :10.1016/S0022-2275(20)31570-4 PMID 11483621 . Jaworski CJ, Moreira E, Li A, et al. (2002). "A family of 12 human genes containing oxysterol-binding domains" . Genomics . 78 (3): 185–96. doi :10.1006/geno.2001.6663 . PMID 11735225 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Higashimoto K, Soejima H, Yatsuki H, et al. (2003). "Characterization and imprinting status of OBPH1/Obph1 gene: implications for an extended imprinting domain in human and mouse". Genomics . 80 (6): 575–84. doi :10.1006/geno.2002.7006 . PMID 12504849 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline" . Genome Res . 14 (10B): 2136–44. doi :10.1101/gr.2576704 . PMC 528930 PMID 15489336 . Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006" . Nucleic Acids Res . 34 (Database issue): D415–8. doi :10.1093/nar/gkj139 . PMC 1347501 PMID 16381901 . Ma J, Dempsey AA, Stamatiou D, et al. (2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects". Atherosclerosis . 191 (1): 63–72. doi :10.1016/j.atherosclerosis.2006.05.032 . PMID 16806233 . Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 .
