OR2H2

Olfactory receptor 2H2 is a protein that in humans is encoded by the OR2H2 gene.

OR2H2
Identifiers
Aliases	OR2H2, FAT11, OLFR2, OLFR42B, OR2H3, dJ271M21.2, hs6M1-12, olfactory receptor family 2 subfamily H member 2
External IDs	OMIM: 600578 MGI: 2177473 HomoloGene: 68546 GeneCards: OR2H2
Gene location (Human) Chr. Chromosome 6 (human) Band 6p22.1 Start 29,585,121 bp End 29,590,500 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 B1 Start 37,394,763 bp End 37,399,391 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in putamen nucleus accumbens caudate nucleus temporal lobe amygdala hippocampus proper hypothalamus superior frontal gyrus dorsolateral prefrontal cortex Brodmann area 9 Top expressed in blastocyst bone marrow conceptus female reproductive system placenta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity olfactory receptor activity Cellular component integral component of membrane plasma membrane membrane Biological process defense response mating signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7932 258469 Ensembl ENSG00000204657 ENSMUSG00000056600 UniProt O95918 n/a RefSeq (mRNA) NM_007160 NM_146477 RefSeq (protein) NP_009091 n/a Location (UCSC) Chr 6: 29.59 – 29.59 Mb Chr 17: 37.39 – 37.4 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

See also

• Olfactory receptor

Further reading

• Fan W, Liu YC, Parimoo S, Weissman SM (1995). "Olfactory receptor-like genes are located in the human major histocompatibility complex". Genomics. 27 (1): 119–23. doi:10.1006/geno.1995.1013. PMID 7665158.
• Fan W, Cai W, Parimoo S, et al. (1996). "Identification of seven new human MHC class I region genes around the HLA-F locus". Immunogenetics. 44 (2): 97–103. doi:10.1007/BF02660056. PMID 8662070. S2CID 21628804.
• Eklund AC, Belchak MM, Lapidos K, et al. (2000). "Polymorphisms in the HLA-linked olfactory receptor genes in the Hutterites". Hum. Immunol. 61 (7): 711–7. doi:10.1016/S0198-8859(00)00132-4. PMID 10880742.
• Younger RM, Amadou C, Bethel G, et al. (2001). "Characterization of clustered MHC-linked olfactory receptor genes in human and mouse". Genome Res. 11 (4): 519–30. doi:10.1101/gr.gr-1603r. PMC 311051. PMID 11282967.
• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. CiteSeerX 10.1.1.135.3652. doi:10.1006/geno.2002.6830. PMID 12213199.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Volz A, Ehlers A, Younger R, et al. (2003). "Complex transcription and splicing of odorant receptor genes". J. Biol. Chem. 278 (22): 19691–701. doi:10.1074/jbc.M212424200. PMID 12637542.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Santos PS, Kellermann T, Uchanska-Ziegler B, et al. (2010). "Genomic architecture of MHC-linked odorant receptor gene repertoires among 16 vertebrate species". Immunogenetics. 62 (9): 569–84. doi:10.1007/s00251-010-0468-6. PMID 20680261. S2CID 23003444.

External links

• OR2H2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.