Neurotensin receptor 2

Neurotensin receptor type 2 is a protein that in humans is encoded by the NTSR2 gene.[5][6][7]

NTSR2
Identifiers
AliasesNTSR2, NTR2, Neurotensin receptor 2
External IDsOMIM: 605538 MGI: 108018 HomoloGene: 7452 GeneCards: NTSR2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012344

NM_008747
NM_001361702
NM_001361703

RefSeq (protein)

NP_036476

NP_032773
NP_001348631
NP_001348632

Location (UCSC)Chr 2: 11.66 – 11.67 MbChr 12: 16.7 – 16.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function edit

The protein encoded by this gene belongs to the G protein-coupled receptor family that activates a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in the brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist.[7]

See also edit

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169006 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020591 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chalon P, Vita N, Kaghad M, Guillemot M, Bonnin J, Delpech B, Le Fur G, Ferrara P, Caput D (May 1996). "Molecular cloning of a levocabastine-sensitive neurotensin binding site". FEBS Letters. 386 (2–3): 91–4. doi:10.1016/0014-5793(96)00397-3. PMID 8647296. S2CID 5802578.
  6. ^ Vita N, Oury-Donat F, Chalon P, Guillemot M, Kaghad M, Bachy A, Thurneyssen O, Garcia S, Poinot-Chazel C, Casellas P, Keane P, Le Fur G, Maffrand JP, Soubrie P, Caput D, Ferrara P (Nov 1998). "Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells". European Journal of Pharmacology. 360 (2–3): 265–72. doi:10.1016/S0014-2999(98)00678-5. PMID 9851594.
  7. ^ a b "Entrez Gene: NTSR2 neurotensin receptor 2".

Further reading edit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

External links edit