Born in the United States and a graduate of the Yeshiva of Flatbush, Hendel graduated New York University in 1973 with a B.A. in sociology and Jewish studies and later studied Talmud at Yeshiva University with Rabbi Joseph B. Soloveitchik. In 1976, he completed his law degree at Hofstra University and became of member of the New York State Bar Association.
In 1983, Hendel made aliyah to Israel, and settled in Beersheba. In 1988, he became a judge on the Beersheba Magistrate's Court, a position he held until 1997. In 1997, he became a judge on the Beersheba District Court, eventually becoming its Vice-President. In 2009, he was appointed to serve on the Supreme Court by the Judicial Selection Committee.
His wife, Marcie, is a psychologist. The couple has five sons.
- "Neal Hendel". Israeli Judicial Authority. Retrieved 24 August 2009.
- Gil Ronen (24 August 2009). "Yeshiva of Flatbush High School graduate appointed to Israel's Supreme Court". Israel National News. Retrieved 24 August 2009.