Nucleoporin 155

NUP155
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5A9Q, 5IJN, 5IJO
Identifiers
Aliases	NUP155, ATFB15, N155, nucleoporin 155kDa, nucleoporin 155
External IDs	OMIM: 606694 MGI: 2181182 HomoloGene: 43155 GeneCards: NUP155
Gene location (Human)
Chr.	Chromosome 5 (human)
End	37,371,106 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	8,190,731 bp
RNA expression pattern
	Top expressed in
	sperm; ; secondary oocyte; ; Achilles tendon; ; embryo; ; ganglionic eminence; ; islet of Langerhans; ; bone marrow cells; ; stromal cell of endometrium; ; skin of abdomen; ; rectum;
	Top expressed in
	spermatocyte; ; internal carotid artery; ; external carotid artery; ; maxillary prominence; ; pineal gland; ; cumulus cell; ; medial ganglionic eminence; ; atrium; ; primitive streak; ; medullary collecting duct;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transporter activity; protein binding; structural constituent of nuclear pore;
Cellular component	nuclear membrane; membrane; nuclear envelope; nuclear pore; nucleus; nuclear pore inner ring; host cell;
Biological process	mRNA transport; nuclear envelope organization; viral transcription; protein sumoylation; mitotic nuclear membrane disassembly; nucleocytoplasmic transport; atrial cardiac muscle cell action potential; regulation of cellular response to heat; protein transport; viral process; intracellular transport of virus; protein import into nucleus; RNA export from nucleus; tRNA export from nucleus; transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery; protein localization to nuclear inner membrane; mRNA export from nucleus; regulation of gene silencing by miRNA; regulation of glycolytic process; transport;
	Sources:Amigo / QuickGO
Orthologs
	9631
	170762
	ENSG00000113569
	ENSMUSG00000022142
	O75694
	Q99P88
	NM_001278312; NM_004298; NM_153485
	NM_133227
	NP_001265241; NP_004289; NP_705618
	NP_573490
	Wikidata
View/Edit Human	View/Edit Mouse

Nucleoporin 155 (Nup155) is a protein that in humans is encoded by the NUP155 gene.^[5]^[6]

Nucleoporins are the main components of the nuclear pore complex (NPC) of eukaryotic cells. They are involved in the bidirectional trafficking of molecules, especially mRNAs and proteins, between the nucleus and the cytoplasm. The protein encoded by this gene does not contain the typical FG repeat sequences found in most vertebrate nucleoporins. Two protein isoforms are encoded by transcript variants of this gene.^[6]

Interactions edit

NUP155 has been shown to interact with GLE1L.^[7]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000113569 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022142 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhang X, Yang H, Corydon MJ, Zhang X, Pedersen S, Korenberg JR, Chen XN, Laporte J, Gregersen N, Niebuhr E, Liu G, Bolund L (Jun 1999). "Localization of a human nucleoporin 155 gene (NUP155) to the 5p13 region and cloning of its cDNA". Genomics. 57 (1): 144–51. doi:10.1006/geno.1999.5741. PMID 10191094.
^ ^a ^b "Entrez Gene: NUP155 nucleoporin 155kDa".
^ Rayala, Heidi J; Kendirgi Frederic; Barry Dianne M; Majerus Philip W; Wente Susan R (Feb 2004). "The mRNA export factor human Gle1 interacts with the nuclear pore complex protein Nup155". Mol. Cell. Proteomics. 3 (2). United States: 145–55. doi:10.1074/mcp.M300106-MCP200. ISSN 1535-9476. PMID 14645504.

Further reading edit

Görlich D, Mattaj IW (1996). "Nucleocytoplasmic transport". Science. 271 (5255): 1513–8. Bibcode:1996Sci...271.1513G. doi:10.1126/science.271.5255.1513. hdl:11858/00-001M-0000-002D-1CAE-4. PMID 8599106.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
Zhang X, Yang H, Yu J, et al. (2002). "Genomic organization, transcript variants and comparative analysis of the human nucleoporin 155 (NUP155) gene". Gene. 288 (1–2): 9–18. doi:10.1016/S0378-1119(02)00470-5. PMID 12034489.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Rayala HJ, Kendirgi F, Barry DM, et al. (2004). "The mRNA export factor human Gle1 interacts with the nuclear pore complex protein Nup155". Mol. Cell. Proteomics. 3 (2): 145–55. doi:10.1074/mcp.M300106-MCP200. PMID 14645504.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hawryluk-Gara LA, Shibuya EK, Wozniak RW (2005). "Vertebrate Nup53 Interacts with the Nuclear Lamina and Is Required for the Assembly of a Nup93-containing Complex". Mol. Biol. Cell. 16 (5): 2382–94. doi:10.1091/mbc.E04-10-0857. PMC 1087243. PMID 15703211.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113569 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022142 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10191094-5] Zhang X, Yang H, Corydon MJ, Zhang X, Pedersen S, Korenberg JR, Chen XN, Laporte J, Gregersen N, Niebuhr E, Liu G, Bolund L (Jun 1999). "Localization of a human nucleoporin 155 gene (NUP155) to the 5p13 region and cloning of its cDNA". Genomics. 57 (1): 144–51. doi:10.1006/geno.1999.5741. PMID 10191094.

[entrez-6] "Entrez Gene: NUP155 nucleoporin 155kDa".

[pmid14645504-7] Rayala, Heidi J; Kendirgi Frederic; Barry Dianne M; Majerus Philip W; Wente Susan R (Feb 2004). "The mRNA export factor human Gle1 interacts with the nuclear pore complex protein Nup155". Mol. Cell. Proteomics. 3 (2). United States: 145–55. doi:10.1074/mcp.M300106-MCP200. ISSN 1535-9476. PMID 14645504.

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