NPB can refer to:
- NAS Parallel Benchmarks, a set of benchmarks developed by the NASA for measuring the performance of supercomputers
- National Printing Bureau of Japan
- Nederlandsche Padvinders Bond, one of the scouting organizations that evolved into Scouting Nederland
- Newport Beach a city in Orange County, California, United States
- Nippon Professional Baseball, the highest level of professional baseball in Japan
- Nitrate-producing bacteria, also known as nitrifying bacteria in the nitrogen cycle
- Northern Black Polished Ware, a period of South Asian history (ca. 700 BC–200 BC)
- Parole Board of Canada, a Canadian government agency
- NPB or n-PB, n-propyl bromide, solvent.
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