NOD1

Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) is a protein receptor that in humans is encoded by the NOD1 gene. It recognizes bacterial molecules and stimulates an immune reaction .

NOD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2B1W, 2DBD, 2NSN, 2NZ7, 4E9M, 4JQW
Identifiers
Aliases	NOD1, CARD4, CLR7.1, NLRC1, nucleotide binding oligomerization domain containing 1
External IDs	OMIM: 605980 MGI: 1341839 HomoloGene: 4440 GeneCards: NOD1
Gene location (Human) Chr. Chromosome 7 (human) Band 7p14.3 Start 30,424,527 bp End 30,478,784 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 B3 Start 54,900,934 bp End 54,949,597 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve right lobe of thyroid gland upper lobe of left lung left lobe of thyroid gland subcutaneous adipose tissue spleen right lung left uterine tube secondary oocyte left ventricle Top expressed in subcutaneous adipose tissue sciatic nerve right lung spleen cervix myocardium of ventricle islet of Langerhans right lung lobe otolith organ white adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein homodimerization activity protein binding peptidoglycan binding identical protein binding cysteine-type endopeptidase activator activity involved in apoptotic process CARD domain binding ATP binding protein-containing complex binding Cellular component cytoplasm cytosol membrane plasma membrane basolateral plasma membrane apical plasma membrane Biological process regulation of apoptotic process defense response detection of biotic stimulus intracellular signal transduction positive regulation of cell death immune system process positive regulation of JNK cascade positive regulation of xenophagy positive regulation of NIK/NF-kappaB signaling cellular response to muramyl dipeptide JNK cascade positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of dendritic cell antigen processing and presentation positive regulation of nitric-oxide synthase activity defense response to bacterium positive regulation of NF-kappaB transcription factor activity protein complex oligomerization detection of bacterium positive regulation of interleukin-1 beta production positive regulation of ERK1 and ERK2 cascade positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of I-kappaB kinase/NF-kappaB signaling inflammatory response activation of cysteine-type endopeptidase activity involved in apoptotic process nucleotide-binding oligomerization domain containing signaling pathway signal transduction positive regulation of stress-activated MAPK cascade defense response to Gram-positive bacterium apoptotic process innate immune response interleukin-1-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10392 107607 Ensembl ENSG00000106100 ENSMUSG00000038058 UniProt Q9Y239 Q8BHB0 RefSeq (mRNA) NM_006092 NM_001354849 NM_001171007 NM_172729 RefSeq (protein) NP_006083 NP_001341778 NP_001164478 NP_766317 Location (UCSC) Chr 7: 30.42 – 30.48 Mb Chr 6: 54.9 – 54.95 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

NOD1 protein contains a caspase recruitment domain (CARD). NOD1 is a member of NOD-like receptor protein family and is a close relative of NOD2. NOD1 is an intracellular pattern recognition receptor, which is similar in structure to resistant proteins of plants, and mediates innate and acquired immunity by recognizing molecules containing D-glutamyl-meso-diaminopimelic acid (iE-DAP) moiety, including bacterial peptidoglycan. Nod1 interacts with RIPK2 through the CARDs of both molecules (See the structure of the NOD1 CARD in the right panel). Stimulation of NOD1 by iE-DAP containing molecules results in activation of the transcription factor NF-κB.

Further reading

• Martinon F, Tschopp J (August 2005). "NLRs join TLRs as innate sensors of pathogens". Trends in Immunology. 26 (8): 447–54. doi:10.1016/j.it.2005.06.004. PMID 15967716.
• Strober W, Murray PJ, Kitani A, Watanabe T (January 2006). "Signalling pathways and molecular interactions of NOD1 and NOD2". Nature Reviews. Immunology. 6 (1): 9–20. doi:10.1038/nri1747. PMID 16493424. S2CID 33505741.
• Inohara N, Koseki T, Lin J, del Peso L, Lucas PC, Chen FF, Ogura Y, Núñez G (September 2000). "An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways". The Journal of Biological Chemistry. 275 (36): 27823–31. doi:10.1074/jbc.M003415200. PMID 10880512.
• Inohara N, Ogura Y, Chen FF, Muto A, Nuñez G (January 2001). "Human Nod1 confers responsiveness to bacterial lipopolysaccharides". The Journal of Biological Chemistry. 276 (4): 2551–4. doi:10.1074/jbc.M009728200. PMID 11058605.
• Chu ZL, Pio F, Xie Z, Welsh K, Krajewska M, Krajewski S, Godzik A, Reed JC (March 2001). "A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis". The Journal of Biological Chemistry. 276 (12): 9239–45. doi:10.1074/jbc.M006309200. PMID 11113115.
• Yoo NJ, Park WS, Kim SY, Reed JC, Son SG, Lee JY, Lee SH (December 2002). "Nod1, a CARD protein, enhances pro-interleukin-1beta processing through the interaction with pro-caspase-1". Biochemical and Biophysical Research Communications. 299 (4): 652–8. doi:10.1016/S0006-291X(02)02714-6. PMID 12459189.
• Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501. S2CID 38880905.
• Stehlik C, Hayashi H, Pio F, Godzik A, Reed JC (August 2003). "CARD6 is a modulator of NF-kappa B activation by Nod1- and Cardiak-mediated pathways". The Journal of Biological Chemistry. 278 (34): 31941–9. doi:10.1074/jbc.M300009200. PMID 12775719.
• Girardin SE, Boneca IG, Carneiro LA, Antignac A, Jéhanno M, Viala J, Tedin K, Taha MK, Labigne A, Zähringer U, Coyle AJ, DiStefano PS, Bertin J, Sansonetti PJ, Philpott DJ (June 2003). "Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan". Science. 300 (5625): 1584–7. Bibcode:2003Sci...300.1584G. doi:10.1126/science.1084677. PMID 12791997. S2CID 1320864.
• Hisamatsu T, Suzuki M, Podolsky DK (August 2003). "Interferon-gamma augments CARD4/NOD1 gene and protein expression through interferon regulatory factor-1 in intestinal epithelial cells". The Journal of Biological Chemistry. 278 (35): 32962–8. doi:10.1074/jbc.M304355200. PMID 12813035.
• Girardin SE, Travassos LH, Hervé M, Blanot D, Boneca IG, Philpott DJ, Sansonetti PJ, Mengin-Lecreulx D (October 2003). "Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2". The Journal of Biological Chemistry. 278 (43): 41702–8. doi:10.1074/jbc.M307198200. PMID 12871942.
• Kim JG, Lee SJ, Kagnoff MF (March 2004). "Nod1 is an essential signal transducer in intestinal epithelial cells infected with bacteria that avoid recognition by toll-like receptors". Infection and Immunity. 72 (3): 1487–95. doi:10.1128/IAI.72.3.1487-1495.2004. PMC 356064. PMID 14977954.
• Damiano JS, Oliveira V, Welsh K, Reed JC (July 2004). "Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses". The Biochemical Journal. 381 (Pt 1): 213–9. doi:10.1042/BJ20031506. PMC 1133779. PMID 15107016.

External links

• NOD1 human gene location in the UCSC Genome Browser.
• NOD1 human gene details in the UCSC Genome Browser.