Methylnitronitrosoguanidine
| Methylnitronitrosoguanidine[1] | |
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1-methyl-2-nitro-1-nitrosoguanidine |
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Other names
N-Methyl-N-nitroso-N′-nitroguanidine; N-Methlyl-N′-nitro-N-nitrosoguanidine |
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| Identifiers | |
| Abbreviations | MNNG |
| CAS number | 70-25-7  |
| PubChem | 9562060 |
| KEGG | C14592 |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C2H5N5O3 |
| Molar mass | 147.09 g/mol |
| Appearance | Yellow crystals |
| Melting point |
118 °C (dec.) |
| Solubility in water | reacts violently, slowly hydrolysed |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
Methylnitronitrosoguanidine (MNNG or MNG) is a biochemical tool used experimentally as a carcinogen and mutagen.[1] It acts by adding alkyl groups to the O6 of guanine and O4 of thymine, which can lead to transition mutations between GC and AT. These changes do not cause a heavy distortion in the double helix of DNA and thus are hard to detect by the DNA mismatch repair system.
In organic chemistry, MNNG is used as a source of diazomethane when reacted with aqueous potassium hydroxide.[2]
MNNG is a probable human carcinogen listed as an IARC Group 2A carcinogen.[3]
References
- ^ a b Merck Index, 11th Edition, 6017.
- ^ Aldrichimica Acta 16 (3). 1983.
- ^ N-METHYL-N'-NITRO-N-NITROSOGUANIDINE (MNNG), International Agency for Research on Cancer
