The MRN complex (MRX complex in yeast) is a protein complex consisting of Mre11, Rad50 and Nbs1 (also known as Nibrin  in humans and as Xrs2 in yeast). In eukaryotes, the MRN/X complex plays an important role in the initial processing of double-strand DNA breaks prior to repair by homologous recombination or non-homologous end joining. The MRN complex binds avidly to double-strand breaks both in vitro and in vivo and may serve to tether broken ends prior to repair by non-homologous end joining or to initiate resection prior to repair by homologous recombination. The MRN complex also participates in activating the checkpoint kinase ATM in response to DNA damage. Production of short single-strand oligonucleotides by Mre11 endonuclease activity has been implicated ATM activation by the MRN complex.
Role in human disease
Mutations in the human Nbs1 subunit of the MRN complex have been implicated in the rare genetic disorder Nijmegen Breakage Syndrome.
- "Atlas of Genetics and Cytogenetics in Oncology and Haematology - NBS1". Retrieved 2008-02-12.
- Lee, JH; Paull, TT (2004 Apr 2). "Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex.". Science (New York, N.Y.) 304 (5667): 93–6. PMID 15064416.
- Lee, JH; Paull, TT (2005 Apr 22). "ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex.". Science (New York, N.Y.) 308 (5721): 551–4. PMID 15790808.
- Jazayeri A, Balestrini A, Garner E, Haber JE, Costanzo V (2008). "Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity". The EMBO Journal 27 (14): 1953–1962. doi:10.1038/emboj.2008.128. PMID 18596698.
- "eMedicine - Nijmegen Breakage Syndrome". Retrieved 2008-02-12.
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