MOP may refer to:
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- CFL's Most Outstanding Player Award
- Major Opportunity Point, tennis terminology used to describe the point 0-30
- NCAA Basketball Tournament Most Outstanding Player in the NCAA basketball tournaments
- Manual of Practice, or Project Resource Manual, published by the Construction Specifications Institute
- Mathematical Olympiad Program, held at the University of Nebraska-Lincoln to train team members for the International Mathematical Olympiad
- Means of production, or MoP, a Marxist concept in economics
- Method of Procedure, a document similar to a Standard Operating Procedure
- mu opioid peptide (MOP) receptor, also referred to as mu Opioid receptor
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