Luis Perdomo may refer to:
- Luis Perdomo (baseball, born 1984), Dominican professional baseball pitcher for the San Diego Padres and Minnesota Twins
- Luis Perdomo (baseball, born 1993), Dominican professional baseball pitcher for the Milwaukee Brewers
- Luis Perdomo (pianist) (born 1971), Venezuelan jazz pianist, based in New York City
This disambiguation page lists articles about people with the same name.
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