Transcontinental Drive began as a main thoroughfare through the Bridgedale subdivision which opened in 1925 during construction of the Airline Highway between Shrewsbury (Metairie) and Kenner. In 1930, it was designated as State Route 1246 in the pre-1955 Louisiana Highway system. Transcontinental Drive was intended to be extended south to Jefferson Highway (State Route 1) to connect with the Huey P. Long Bridge then in the planning stages. These plans never came to fruition, and the Bridgedale area would not be not directly connected to the bridge for almost fifty years via an extension of Clearview Parkway.
The route became LA 611-11 in the 1955 Louisiana Highway renumbering and assumed its present number in 1972. The route was returned to local control by 1986.