This is a list of the Spanish PROMUSICAE Top 20 physical Singles number-ones of 2008.[1][2]
| Issue date | Artist | Song |
|---|---|---|
| 6 January | Dogma Crew | "Nacen de la bruma" |
| 13 January | ||
| 20 January | ||
| 27 January | ||
| 3 February | ||
| 10 February | Cast Of High School Musical | "Be Mine" |
| 17 February | ||
| 24 February | ||
| 2 March | ||
| 9 March | ||
| 16 March | ||
| 23 March | Mónica Naranjo | "Europa" |
| 30 March | ||
| 6 April | ||
| 13 April | ||
| 20 April | ||
| 27 April | ||
| 4 May | La Habitación Roja | "Esta no será otra canción de amor" |
| 11 May | Madonna featuring Justin Timberlake | "4 Minutes" |
| 18 May | The Cure | "The Only One" |
| 25 May | ||
| 1 June | ||
| 8 June | ||
| 15 June | Madonna featuring Justin Timberlake | "4 Minutes" |
| 22 June | The Cure | "Freakshow" |
| 29 June | ||
| 6 July | ||
| 13 July | ||
| 20 July | The Cure | "Sleep When I'm Dead" |
| 27 July | Mónica Naranjo | "Amor y lujo" |
| 3 August | ||
| 10 August | ||
| 17 August | ||
| 24 August | Madonna | "Give It 2 Me" |
| 31 August | ||
| 7 September | ||
| 14 September | ||
| 21 September | The Cure | "Hypnagogic States" |
| 28 September | ||
| 5 October | Cast Of High School Musical | "Be Mine" |
| 12 October | ||
| 19 October | ||
| 26 October | Cooper | "Lemon Pop" |
| 2 November | ||
| 9 November | ||
| 16 November | ||
| 23 November | ||
| 30 November | ||
| 7 December | ||
| 14 December | Madonna | "Miles Away" |
| 21 December | ||
| 28 December | Anastacia | "Pieces of a Dream" |