Leadzyme
Leadzyme is a small ribozyme that was artificially made using in vitro selection techniques. Leadzyme is able to cleave RNA in the presence of lead.[1] The structure of leadzyme has been determined by X-ray crystallography.[2]
It has been proposed that a naturally occurring leadzyme occurs in the 5S rRNA and further that this may be an important mechanism in lead toxicity.[3]
References
- ^ Pan T, Uhlenbeck OC (1992). "In vitro selection of RNAs that undergo autolytic cleavage with Pb2+". Biochemistry 31 (16): 3887–3895. doi:10.1021/bi00131a001. PMID 1373649.
- ^ Wedekind JE, McKay DB. (2003). "Crystal structure of the leadzyme at 1.8 A resolution: metal ion binding and the implications for catalytic mechanism and allo site ion regulation". Biochemistry 42 (32): 9554–9563. doi:10.1021/bi0300783. PMID 12911297.
- ^ Barciszewska MZ, Wyszko E, Bald R, Erdmann VA, Barciszewski J. (2003). "5S rRNA is a leadzyme. A molecular basis for lead toxicity". J. Biochemistry 133 (3): 309–315. doi:10.1093/jb/mvg042. PMID 12761166.
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