Laninamivir (CS-8958) is a neuraminidase inhibitor that is a drug used for the treatment and prophylaxis of Influenzavirus A and Influenzavirus B.[1] It is currently in Phase III clinical trials.[2] It is a long-acting neuraminidase inhibitor administered by nasal inhalation.[3]
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| Routes of administration | Inhalation |
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| Formula | C13H22N4O7 |
| Molar mass | 346.340 g·mol−1 |
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Laninamivir was approved for influenza treatment in Japan in 2010 and for prophylaxis in 2013. It is currently marketed under the name Inavir by Daiichi Sankyo. Biota Pharmaceuticals [4] and Daiichi Sankyo co-own Laninamivir. On 1 April 2011, BARDA awarded up to an estimated U$231m to Biota Pharmaceuticals (Formerly Biota Holdings Ltd) wholly owned subsidiary, Biota Scientific Management Pty Ltd, for the advanced development of Laninamivir in the US.[5] It is under clinical evaluations in other countries.[3][6]
References edit
- ^ Yamashita M, Tomozawa T, Kakuta M, Tokumitsu A, Nasu H, Kubo S (January 2009). "CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity". Antimicrobial Agents and Chemotherapy. 53 (1): 186–192. doi:10.1128/AAC.00333-08. PMC 2612152. PMID 18955520.
- ^ Hayden F (January 2009). "Developing new antiviral agents for influenza treatment: what does the future hold?". Clinical Infectious Diseases. 48. 48 Suppl 1 (S1): S3-13. doi:10.1086/591851. PMID 19067613.
- ^ a b Samson M, Pizzorno A, Abed Y, Boivin G (May 2013). "Influenza virus resistance to neuraminidase inhibitors". Antiviral Research. 98 (2): 174–185. doi:10.1016/j.antiviral.2013.03.014. PMID 23523943.
- ^ "Aviragen Therapeutics - Home". Archived from the original on 2016-04-17. Retrieved 2013-04-12.
- ^ "Biota Pharmaceuticals - Home". Archived from the original on 2016-03-05. Retrieved 2013-04-12.
- ^ Ishjida T (2020). "Treatment Guidelines for Influenza Virus Infection: What Does the Recent Guideline State?". In Fujita J (ed.). Influenza: Advances in Diagnosis and Management. Respiratory Disease Series: Diagnostic Tools and Disease Managements. Singapore: Springer. pp. 129–136 (132). doi:10.1007/978-981-15-9109-9_13. ISBN 978-981-15-9109-9. S2CID 228892521.
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