KRT23

KRT23
Identifiers
Aliases	KRT23, CK23, HAIK1, K23, keratin 23
External IDs	OMIM: 606194 MGI: 2148866 HomoloGene: 9172 GeneCards: KRT23
Gene location (Human)
Chr.	Chromosome 17 (human)
End	40,937,646 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	99,383,963 bp
RNA expression pattern
	Top expressed in
	placenta; ; skin of abdomen; ; salivary gland; ; minor salivary glands; ; blood; ; islet of Langerhans; ; thymus; ; right uterine tube; ; prostate; ; gallbladder;
	Top expressed in
	otic placode; ; esophagus; ; epithelium of stomach; ; lip; ; submandibular gland; ; skin of back; ; saccule; ; parotid gland; ; mucous cell of stomach; ; pyloric antrum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural molecule activity;
Cellular component	intermediate filament; cytosol;
Biological process	keratinization; cornification;
	Sources:Amigo / QuickGO
Orthologs
	25984
	94179
	ENSG00000108244; ENSG00000263309
	ENSMUSG00000006777
	Q9C075
	Q99PS0
	NM_001282433; NM_015515; NM_173213
	NM_033373
	NP_001269362; NP_056330
	NP_203537
	Wikidata
View/Edit Human	View/Edit Mouse

Keratin, type I cytoskeletal 23 is a protein that in humans is encoded by the KRT23 gene.^[5]^[6]^[7]

The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratin and hair keratin. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21.^[7]

References edit

^ ^a ^b ^c ENSG00000263309 GRCh38: Ensembl release 89: ENSG00000108244, ENSG00000263309 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006777 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhang JS, Wang L, Huang H, Nelson M, Smith DI (Jan 2001). "Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells". Genes Chromosomes Cancer. 30 (2): 123–35. doi:10.1002/1098-2264(2000)9999:9999<::AID-GCC1070>3.0.CO;2-W. PMID 11135429. S2CID 40237049.
^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
^ ^a ^b "Entrez Gene: KRT23 keratin 23 (histone deacetylase inducible)".

Further reading edit

Suzuki A, Ji G, Numabe Y, et al. (2004). "Single nucleotide polymorphisms associated with aggressive periodontitis and severe chronic periodontitis in Japanese". Biochem. Biophys. Res. Commun. 317 (3): 887–92. doi:10.1016/j.bbrc.2004.03.126. PMID 15081423.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Tolstonog GV, Sabasch M, Traub P (2002). "Cytoplasmic intermediate filaments are stably associated with nuclear matrices and potentially modulate their DNA-binding function". DNA Cell Biol. 21 (3): 213–39. doi:10.1089/10445490252925459. PMID 12015898.
Hesse M, Magin TM, Weber K (2002). "Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18". J. Cell Sci. 114 (Pt 14): 2569–75. doi:10.1242/jcs.114.14.2569. PMID 11683385.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000263309 GRCh38: Ensembl release 89: ENSG00000108244, ENSG00000263309 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000006777 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11135429-5] Zhang JS, Wang L, Huang H, Nelson M, Smith DI (Jan 2001). "Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells". Genes Chromosomes Cancer. 30 (2): 123–35. doi:10.1002/1098-2264(2000)9999:9999<::AID-GCC1070>3.0.CO;2-W. PMID 11135429. S2CID 40237049.

[pmid16831889-6] Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.

[entrez-7] "Entrez Gene: KRT23 keratin 23 (histone deacetylase inducible)".

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