KIF5C

Kinesin heavy chain isoform 5C is a protein that in humans is encoded by the KIF5C gene. It is part of the kinesin family of motor proteins.

KIF5C
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1VFV, 1VFW, 1VFX, 1VFZ, 3J6H, 3WRD, 3X2T
Identifiers
Aliases	KIF5C, CDCBM2, KINN, NKHC, NKHC-2, NKHC2, kinesin family member 5C
External IDs	OMIM: 604593 MGI: 1098269 HomoloGene: 56234 GeneCards: KIF5C
Gene location (Human) Chr. Chromosome 2 (human) Band 2q23.1-q23.2 Start 148,875,227 bp End 149,026,759 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 C1.1|2 28.68 cM Start 49,509,310 bp End 49,664,790 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 10 frontal pole cerebellar vermis middle temporal gyrus middle frontal gyrus Brodmann area 46 postcentral gyrus Brodmann area 23 orbitofrontal cortex endothelial cell Top expressed in globus pallidus substantia nigra cerebellar vermis lateral geniculate nucleus facial motor nucleus ventral tegmental area subiculum lateral hypothalamus pontine nuclei medial geniculate nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function microtubule motor activity nucleotide binding microtubule binding protein binding plus-end-directed microtubule motor activity ATP binding ATPase activity Cellular component cytoplasm kinesin complex ciliary rootlet neuron projection microtubule cytoskeleton dendrite dendrite cytoplasm cell projection neuronal cell body axonal growth cone synapse distal axon axon cytoplasm Biological process protein localization cytoskeleton-dependent intracellular transport mRNA transport organelle organization axon guidance microtubule-based movement motor neuron axon guidance synaptic vesicle transport anterograde dendritic transport of neurotransmitter receptor complex anterograde axonal protein transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3800 16574 Ensembl ENSG00000168280 ENSG00000276734 ENSMUSG00000026764 UniProt O60282 P28738 RefSeq (mRNA) NM_004522 NM_008449 RefSeq (protein) NP_004513 NP_032475 Location (UCSC) Chr 2: 148.88 – 149.03 Mb Chr 2: 49.51 – 49.66 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Engelender S, Sharp AH, Colomer V, et al. (1998). "Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin". Hum. Mol. Genet. 6 (13): 2205–12. doi:10.1093/hmg/6.13.2205. PMID 9361024.
• Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
• Xia Ch; Rahman A; Yang Z; Goldstein LS (1998). "Chromosomal localization reveals three kinesin heavy chain genes in mouse". Genomics. 52 (2): 209–13. doi:10.1006/geno.1998.5427. PMID 9782088.
• Junco A, Bhullar B, Tarnasky HA, van der Hoorn FA (2001). "Kinesin light-chain KLC3 expression in testis is restricted to spermatids". Biol. Reprod. 64 (5): 1320–30. doi:10.1095/biolreprod64.5.1320. PMC 3161965. PMID 11319135.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Brickley K, Smith MJ, Beck M, Stephenson FA (2005). "GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin". J. Biol. Chem. 280 (15): 14723–32. doi:10.1074/jbc.M409095200. PMID 15644324.
• Smith MJ, Pozo K, Brickley K, Stephenson FA (2006). "Mapping the GRIF-1 binding domain of the kinesin, KIF5C, substantiates a role for GRIF-1 as an adaptor protein in the anterograde trafficking of cargoes". J. Biol. Chem. 281 (37): 27216–28. doi:10.1074/jbc.M600522200. PMID 16835241.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

• Overview of all the structural information available in the PDB for UniProt: P28738 (Mouse Kinesin heavy chain isoform 5C) at the PDBe-KB.