Isa or ISA may refer to:

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  • Īsā, the name of Jesus in Islam
  • Isa (name), an Arabic name corresponding to Jesus in English
  • Isa, stage name of Lee Chae-young, member of K-Pop group STAYC
  • Isa, female given name, short for Isabel or similar names beginning with Isa- such as Isadora
  • Isa Maud Ilsen (1868–1937), Canadian-American music therapist, nurse, lecturer
  • Isa Tengblad (born 1998), Swedish singer using the mononym Isa
  • Juan Isa (1913–1993), president of the International Baseball Federation (FIBA) from 1969 to 1975

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