Housatonic may refer to one of the following.
In the United States:
- The Housatonic River, a river in western Massachusetts and western Connecticut, and the source for other uses of the word
- Housatonic, Massachusetts, a census-designated place in the town of Great Barrington
- Housatonic Railroad, a railroad that operated independently 1836–1892, as a subsidiary 1892–1970s, and a separate company started in 1983 in western Connecticut
- Housatonic Valley, the valley and watershed of the Housatonic River
- Housatonic Community College in southern Connecticut
- Housatonic Valley Regional High School, Falls Village, Connecticut
- USS Housatonic, three United States Navy vessels, including the first ship to be sunk by a submarine
- SS Georgia (1890), a German passenger liner seized by the United States during World War I, renamed Housatonic, and sunk by a German submarine
- A dialect of the Unami language
- An American nuclear weapon test of the Operation Dominic I and II series
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