HIV ribosomal frameshift signal
| HIV Ribosomal frameshift signal | |
|---|---|
 |
|
| Predicted secondary structure and sequence conservation of HIV_FE | |
| Identifiers | |
| Symbol | HIV_FE |
| Rfam | RF00480 |
| Other data | |
| RNA type | Cis-reg; frameshift_element |
| Domain(s) | Viruses |
| SO | 0000233 |
The HIV ribosomal frameshift signal is an RNA element. HIV uses a system called −1 ribosomal frameshifting to produce the required ratio of Gag and Gag-Pol polyproteins. The stem-loop structure of the frameshift signal is thought to impede the ribosome and cause slippage in the 5' direction, this causes the −1 frameshift and translation then continues in the new frame.[1]
References
- ^ Biswas, P; Jiang X, Pacchia AL, Dougherty JP, Peltz SW (2004). "The human immunodeficiency virus type 1 ribosomal frameshifting site is an invariant sequence determinant and an important target for antiviral therapy". J Virol 78 (4): 2082–2087. doi:10.1128/JVI.78.4.2082-2087.2004. PMC 369415. PMID 14747573.
External links
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