Histone H2A type 1 is a protein that in humans is encoded by the HIST1H2AL gene.[5][6][7][8]

H2AC16
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesH2AC16, H2A.i, H2A/i, H2AFI, dJ193B12.9, histone cluster 1, H2al, histone cluster 1 H2A family member l, H2A clustered histone 16, HIST1H2AL, H2AC11, H2AC15, H2AC17, H2AC13
External IDsOMIM: 602793 MGI: 2448290 HomoloGene: 136768 GeneCards: H2AC16
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003511

NM_178187

RefSeq (protein)

NP_066408
NP_003505

Location (UCSC)Chr 6: 27.87 – 27.87 MbChr 13: 23.75 – 23.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.[8]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000276903 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000069272 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Albig W, Doenecke D (Feb 1998). "The human histone gene cluster at the D6S105 locus". Hum Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. S2CID 38539096.
  6. ^ Albig W, Meergans T, Doenecke D (Mar 1997). "Characterization of the H1.5 gene completes the set of human H1 subtype genes". Gene. 184 (2): 141–8. doi:10.1016/S0378-1119(96)00582-3. PMID 9031620.
  7. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  8. ^ a b "Entrez Gene: HIST1H2AL histone cluster 1, H2al".

Further reading edit