Guillermo Diaz may refer to:
- Guillermo Díaz (actor), an American actor
- Guillermo Diaz (basketball) (born 1985), Puerto Rican basketball player
- Guillermo Díaz (Jimmy Kimmel Live!), talk show sidekick for Jimmy Kimmel Live!
- Guillermo Díaz Gastambide, professional football player
- Guillermo Díaz (Chilean footballer)
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