Glycoprotein IIb/IIIa
| integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | |
|---|---|
| Identifiers | |
| Symbol | ITGA2B |
| Alt. symbols | GP2B |
| Entrez | 3674 |
| HUGO | 6138 |
| OMIM | 607759 |
| RefSeq | NM_000419 |
| UniProt | P08514 |
| Other data | |
| Locus | Chr. 17 q21.32 |
| integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | |
|---|---|
| Identifiers | |
| Symbol | ITGB3 |
| Alt. symbols | GP3A |
| Entrez | 3690 |
| HUGO | 6156 |
| OMIM | 173470 |
| RefSeq | NM_000212 |
| UniProt | P05106 |
| Other data | |
| Locus | Chr. 17 q21.32 |
In medicine, glycoprotein IIb/IIIa (gpIIb/IIIa, also known as integrin αIIbβ3) is an integrin complex found on platelets. It is a receptor for fibrinogen[1] and aids in platelet activation. The complex is formed via calcium-dependent association of gpIIb and gpIIIa, a required step in normal platelet aggregation and endothelial adherence.[2][3] Platelet activation by ADP (blocked by clopidogrel) leads to a conformational change in platelet gpIIb/IIIa receptors that induces binding to fibrin.[1] The gpIIb/IIIa receptor is a target of several drugs including abciximab, eptifibatide, tirofiban.
Pathology
Defects in glycoprotein IIb/IIIa cause Glanzmann's thrombasthenia.[4]
Autoantibodies against IIb/IIIa can be produced in immune thrombocytopenic purpura.[5]
Medicine
Glycoprotein IIb/IIIa inhibitors can be used to prevent blood clots in an effort to decrease the risk of heart attack or stroke.
References
- ^ a b Vickers JD (July 1999). "Binding of polymerizing fibrin to integrin alpha(IIb)beta(3) on chymotrypsin-treated rabbit platelets decreases phosphatidylinositol 4,5-bisphosphate and increases cytoskeletal actin". Platelets 10 (4): 228–37. doi:10.1080/09537109976077. PMID 16801097.
- ^ Calvete JJ (1995). "On the structure and function of platelet integrin alpha IIb beta 3, the fibrinogen receptor". Proc. Soc. Exp. Biol. Med. 208 (4): 346–60. PMID 7535429.
- ^ Shattil SJ (1999). "Signaling through platelet integrin alpha IIb beta 3: inside-out, outside-in, and sideways". Thromb. Haemost. 82 (2): 318–25. PMID 10605720.
- ^ Bellucci S, Caen J (2002). "Molecular basis of Glanzmann's Thrombasthenia and current strategies in treatment". Blood Rev. 16 (3): 193–202. doi:10.1016/S0268-960X(02)00030-9. PMID 12163005.
- ^ McMillan R (October 2007). "The pathogenesis of chronic immune thrombocytopenic purpura". Semin. Hematol. 44 (4 Suppl 5): S3–S11. doi:10.1053/j.seminhematol.2007.11.002. PMID 18096470.
External links
- Glycoproteins IIb-IIIa at the US National Library of Medicine Medical Subject Headings (MeSH)
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