G cell
| G cell | |
|---|---|
 |
|
| Control of stomach acid | |
| Latin | endocrinocytus G |
| Code | TH H3.04.02.0.00031 |
In anatomy, the G cell is a type of cell in the stomach that secretes gastrin. It works in conjunction with gastric chief cells and parietal cells.
G cells are found deep within the gastric glands of the stomach antrum, and occasionally in the pancreas.[1]
The vagus nerve innervates the G cells.
Gastrin-releasing peptide is released by the post-ganglionic fibers of the vagus nerve onto G cells during parasympathetic stimulation. The peptide hormone bombesin also stimulates gastrin release from G cells.
Gastrin-releasing peptide, as well as the presence of amino acids in the stomach, stimulates the release of gastrin from the G cells. Gastrin stimulates enterochromaffin-like cells to release histamine.[2]
Gastrin also targets parietal cells by increasing the amount of histamine and the direct stimulation by gastrin, causing the parietal cells to increase HCl secretion in the stomach.
Histomorphology
G cell have a distinctive microscopic appearance that allows one to separate them from other cells in the gastric antrum; their nucleus is centrally located in the cell and the cytoplasm is clear. They are found in the mid portion of the gastric glands
References
- ^ iv_1/g/G_cell article at GE's Medcyclopaedia
- ^ Guyton, Arthur C.; John E. Hall (2006). Textbook of Medical Physiology (11 ed.). Philadelphia: Elsevier Saunders. p. 797. ISBN 0-7216-0240-1.
External links
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