GSTO1

Glutathione S-transferase omega 1
PDB rendering based on 1eem.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1EEM, 3LFL, 3VLN, 4IS0
Identifiers
Symbols	GSTO1; GSTO 1-1; GSTTLp28; P28; SPG-R
External IDs	OMIM: 605482 MGI: 1342273 HomoloGene: 37971 ChEMBL: 3174 GeneCards: GSTO1 Gene
EC number	1.20.4.2, 1.8.5.1, 2.5.1.18
Gene Ontology Molecular function • glutathione transferase activity • oxidoreductase activity • glutathione dehydrogenase (ascorbate) activity • methylarsonate reductase activity Cellular component • cytoplasm • cytosol Biological process • xenobiotic metabolic process • regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion • positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion • L-ascorbic acid metabolic process • xenobiotic catabolic process • small molecule metabolic process • negative regulation of ryanodine-sensitive calcium-release channel activity • positive regulation of ryanodine-sensitive calcium-release channel activity • cellular response to arsenic-containing substance Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9446	14873
Ensembl	ENSG00000148834	ENSMUSG00000025068
UniProt	P78417	O09131
RefSeq (mRNA)	NM_001191002	NM_010362
RefSeq (protein)	NP_001177931	NP_034492
Location (UCSC)	Chr 10: 106 – 106.03 Mb	Chr 19: 47.85 – 47.86 Mb
PubMed search	[1]	[2]

Glutathione S-transferase omega-1 is an enzyme that in humans is encoded by the GSTO1 gene.

This gene encodes a member of the theta class glutathione S-transferase-like (GSTTL) protein family. In mouse, the encoded protein acts as a small stress response protein, likely involved in cellular redox homeostasis. This protein has dehydroascorbate reductase activity and may function in the glutathione-ascorbate cycle as part of antioxidant metabolism.

Further reading

• Matoba R, Okubo K, Hori N et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819. 
• Ishikawa T, Casini AF, Nishikimi M (1998). "Molecular cloning and functional expression of rat liver glutathione-dependent dehydroascorbate reductase". J. Biol. Chem. 273 (44): 28708–12. doi:10.1074/jbc.273.44.28708. PMID 9786866. 
• Kodym R, Calkins P, Story M (1999). "The cloning and characterization of a new stress response protein. A mammalian member of a family of theta class glutathione s-transferase-like proteins". J. Biol. Chem. 274 (8): 5131–7. doi:10.1074/jbc.274.8.5131. PMID 9988762. 
• Hubbard MJ, McHugh NJ (2001). "Human ERp29: isolation, primary structural characterisation and two-dimensional gel mapping". Electrophoresis 21 (17): 3785–96. doi:10.1002/1522-2683(200011)21:17<3785::AID-ELPS3785>3.0.CO;2-2. PMID 11271497. 
• Yin ZL, Dahlstrom JE, Le Couteur DG, Board PG (2001). "Immunohistochemistry of omega class glutathione S-transferase in human tissues". J. Histochem. Cytochem. 49 (8): 983–7. doi:10.1177/002215540104900806. PMID 11457926. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Tanaka-Kagawa T, Jinno H, Hasegawa T et al. (2003). "Functional characterization of two variant human GSTO 1-1s (Ala140Asp and Thr217Asn)". Biochem. Biophys. Res. Commun. 301 (2): 516–20. doi:10.1016/S0006-291X(02)03066-8. PMID 12565892. 
• Yu L, Kalla K, Guthrie E et al. (2004). "Genetic variation in genes associated with arsenic metabolism: glutathione S-transferase omega 1-1 and purine nucleoside phosphorylase polymorphisms in European and indigenous Americans". Environ. Health Perspect. 111 (11): 1421–7. doi:10.1289/ehp.6420. PMC 1241635. PMID 12928150. 
• Li YJ, Oliveira SA, Xu P et al. (2004). "Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease". Hum. Mol. Genet. 12 (24): 3259–67. doi:10.1093/hmg/ddg357. PMID 14570706. 
• Whitbread AK, Mellick GD, Silburn PA et al. (2004). "Glutathione transferase Omega class polymorphisms in Parkinson disease". Neurology 62 (10): 1910–1. PMID 15159516. 
• Deloukas P, Earthrowl ME, Grafham DV et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Kölsch H, Linnebank M, Lütjohann D et al. (2005). "Polymorphisms in glutathione S-transferase omega-1 and AD, vascular dementia, and stroke". Neurology 63 (12): 2255–60. PMID 15623683. 
• Ozturk A, Desai PP, Minster RL et al. (2005). "Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's disease". Neurobiol. Aging 26 (8): 1161–5. doi:10.1016/j.neurobiolaging.2004.11.001. PMID 15917099. 
• Stelzl U, Worm U, Lalowski M et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 
• Fujihara J, Kunito T, Takeshita H (2007). "Frequency of two human glutathione-S-transferase omega-1 polymorphisms (E155 deletion and E208K) in Ovambo and Japanese populations using the PCR-based genotyping method". Clin. Chem. Lab. Med. 45 (5): 621–4. doi:10.1515/CCLM.2007.128. PMID 17484623. 
• Harju TH, Peltoniemi MJ, Rytilä PH et al. (2007). "Glutathione S-transferase omega in the lung and sputum supernatants of COPD patients". Respir. Res. 8 (1): 48. doi:10.1186/1465-9921-8-48. PMC 1939846. PMID 17617905. 
• Kölsch H, Larionov S, Dedeck O et al. (2007). "Association of the glutathione S-transferase omega-1 Ala140Asp polymorphism with cerebrovascular atherosclerosis and plaque-associated interleukin-1 alpha expression". Stroke 38 (10): 2847–50. doi:10.1161/STROKEAHA.107.484162. PMID 17717316.