GSG2

Serine/threonine-protein kinase haspin is an enzyme that in humans is encoded by the GSG2 gene.

HASPIN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2VUW, 2WB8, 3DLZ, 3E7V, 3F2N, 3FMD, 3IQ7, 4OUC, 4QTC, 5HTC, 5HTB
Identifiers
Aliases	HASPIN, GSG2, germ cell associated 2, haspin, histone H3 associated protein kinase
External IDs	OMIM: 609240 MGI: 1194498 HomoloGene: 49236 GeneCards: HASPIN
Gene location (Human) Chr. Chromosome 17 (human) Band 17p13.2 Start 3,723,903 bp End 3,726,699 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 B4|11 45.25 cM Start 73,026,311 bp End 73,029,120 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell secondary oocyte tibialis anterior muscle ganglionic eminence bone marrow cells sperm stromal cell of endometrium appendix lymph node rectum Top expressed in spermatid seminiferous tubule spermatocyte secondary oocyte primitive streak abdominal wall otic placode morula thymus yolk sac More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding kinase activity protein serine/threonine kinase activity protein binding histone kinase activity (H3-T3 specific) ATP binding protein kinase activity Cellular component cytoplasm centrosome chromosome cytoskeleton nucleus spindle Biological process intracellular signal transduction phosphorylation mitotic sister chromatid cohesion protein localization to chromosome, centromeric region cell cycle protein phosphorylation chromatin organization mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83903 14841 Ensembl ENSG00000177602 ENSMUSG00000050107 UniProt Q8TF76 Q9Z0R0 RefSeq (mRNA) NM_031965 NM_010353 RefSeq (protein) NP_114171 NP_034483 Location (UCSC) Chr 17: 3.72 – 3.73 Mb Chr 11: 73.03 – 73.03 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Dai J, Sullivan BA, Higgins JM (2007). "Regulation of mitotic chromosome cohesion by Haspin and Aurora B." Dev. Cell. 11 (5): 741–50. doi:10.1016/j.devcel.2006.09.018. PMID 17084365.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Dai J, Sultan S, Taylor SS, Higgins JM (2005). "The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment". Genes Dev. 19 (4): 472–88. doi:10.1101/gad.1267105. PMC 548948. PMID 15681610.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Higgins JM (2001). "The Haspin gene: location in an intron of the integrin alphaE gene, associated transcription of an integrin alphaE-derived RNA and expression in diploid as well as haploid cells". Gene. 267 (1): 55–69. doi:10.1016/S0378-1119(01)00387-0. PMID 11311556.
• Tanaka H, Iguchi N, Nakamura Y, et al. (2001). "Cloning and characterization of human haspin gene encoding haploid germ cell-specific nuclear protein kinase". Mol. Hum. Reprod. 7 (3): 211–8. doi:10.1093/molehr/7.3.211. PMID 11228240.