GSC (gene)

Goosecoid homeobox
PDB rendering based on 2dmu.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2DMU
Identifiers
Symbol	GSC
External IDs	OMIM: 138890 MGI: 95841 HomoloGene: 7744 GeneCards: GSC Gene
Gene Ontology Molecular function • RNA polymerase II transcription factor binding • RNA polymerase II repressing transcription factor binding • DNA binding • sequence-specific DNA binding transcription factor activity • sequence-specific DNA binding Cellular component • nucleus • transcription factor complex Biological process • negative regulation of transcription from RNA polymerase II promoter • gastrulation • dorsal/ventral neural tube patterning • signal transduction involved in regulation of gene expression • negative regulation of Wnt receptor signaling pathway • forebrain development • middle ear morphogenesis • muscle organ morphogenesis • embryonic skeletal system morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	145258	14836
Ensembl	ENSG00000133937	ENSMUSG00000021095
UniProt	P56915	Q02591
RefSeq (mRNA)	NM_173849	NM_010351
RefSeq (protein)	NP_776248	NP_034481
Location (UCSC)	Chr 14: 95.23 – 95.24 Mb	Chr 12: 104.47 – 104.47 Mb
PubMed search	[1]	[2]

Homeobox protein goosecoid is a protein that in humans is encoded by the GSC gene.

This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. The encoded protein acts as a transcription factor and may be autoregulatory. A similar protein in mice plays a role in craniofacial and rib cage development during embryogenesis.

Further reading

• Schlade-Bartusiak K, Macintyre G, Zunich J, Cox DW (2008). "A child with deletion (14)(q24.3q32.13) and auditory neuropathy". Am. J. Med. Genet. A 146 (1): 117–123. doi:10.1002/ajmg.a.32064. PMID 18074379. 
• Hartwell KA, Muir B, Reinhardt F et al. (2007). "The Spemann organizer gene, Goosecoid, promotes tumor metastasis". Proc. Natl. Acad. Sci. U.S.A. 103 (50): 18969–18974. doi:10.1073/pnas.0608636103. PMC 1748161. PMID 17142318. 
• Barrios-Rodiles M, Brown KR, Ozdamar B et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science 307 (5715): 1621–1625. doi:10.1126/science.1105776. PMID 15761153. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Namciu SJ, Friedman RD, Marsden MD et al. (2004). "Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1". Mamm. Genome 15 (3): 162–178. doi:10.1007/s00335-003-2311-y. PMID 15014966. 
• Foucher I, Montesinos ML, Volovitch M et al. (2003). "Joint regulation of the MAP1B promoter by HNF3beta/Foxa2 and Engrailed is the result of a highly conserved mechanism for direct interaction of homeoproteins and Fox transcription factors". Development 130 (9): 1867–1876. doi:10.1242/dev.00414. PMID 12642491. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Danilov V, Blum M, Schweickert A et al. (1998). "Negative autoregulation of the organizer-specific homeobox gene goosecoid". J. Biol. Chem. 273 (1): 627–635. doi:10.1074/jbc.273.1.627. PMID 9417125. 

External links

• The Goosecoid Page