GRIP1 (gene)

Not to be confused with glucocorticoid receptor-interacting protein 1.

Glutamate receptor-interacting protein 1 is a protein that in humans is encoded by the GRIP1 gene.

GRIP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JIL
Identifiers
Aliases	GRIP1, GRIP, glutamate receptor interacting protein 1, FRASRS3
External IDs	OMIM: 604597 MGI: 1921303 HomoloGene: 12938 GeneCards: GRIP1
Gene location (Human) Chr. Chromosome 12 (human) Band 12q14.3 Start 66,347,431 bp End 67,069,162 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10 D2|10 67.33 cM Start 119,289,735 bp End 119,923,166 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence seminal vesicula secondary oocyte skin of abdomen placenta right uterine tube endothelial cell minor salivary glands left lobe of thyroid gland prefrontal cortex Top expressed in spermatid seminiferous tubule habenula secondary oocyte olfactory bulb barrel cortex motor neuron pineal gland ganglionic eminence trigeminal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function beta-catenin binding transcription coactivator activity protein C-terminus binding protein binding androgen receptor binding glucocorticoid receptor binding signaling receptor complex adaptor activity Cellular component recycling endosome cytosol postsynaptic membrane membrane plasma membrane synapse cell junction dendrite endoplasmic reticulum membrane raft neuron projection cytoplasmic vesicle glutamatergic synapse Biological process protein localization androgen receptor signaling pathway intracellular signal transduction dendrite development positive regulation of transcription, DNA-templated neurotransmitter receptor transport, endosome to postsynaptic membrane vesicle-mediated transport in synapse positive regulation of neuron projection arborization positive regulation of signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23426 74053 Ensembl ENSG00000155974 ENSMUSG00000034813 UniProt Q9Y3R0 Q925T6 RefSeq (mRNA) NM_001178074 NM_021150 NM_001366722 NM_001366723 NM_001366724 NM_001379345 NM_001379346 NM_001379347 NM_001379348 NM_001379349 NM_001379351 NM_001277292 NM_001277293 NM_001277294 NM_001277295 NM_028736 NM_130891 NM_133442 NM_001358809 NM_001358810 NM_001358811 RefSeq (protein) NP_001171545 NP_066973 NP_001353651 NP_001353652 NP_001353653 NP_001366274 NP_001366275 NP_001366276 NP_001366277 NP_001366278 NP_001366280 NP_001264221 NP_001264222 NP_001264223 NP_001264224 NP_083012 NP_570961 NP_597699 NP_001345738 NP_001345739 NP_001345740 Location (UCSC) Chr 12: 66.35 – 67.07 Mb Chr 10: 119.29 – 119.92 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

GRIP1 (gene) has been shown to interact with:

• GRM3,
• GRIA2,
• GRIA3,
• GRIA4,
• GRIK2, and
• GRIK3.

Further reading

• Irvine RA, Ma H, Yu MC, et al. (2000). "Inhibition of p160-mediated coactivation with increasing androgen receptor polyglutamine length". Hum. Mol. Genet. 9 (2): 267–74. doi:10.1093/hmg/9.2.267. PMID 10607837.
• Teyssier C, Belguise K, Galtier F, Chalbos D (2001). "Characterization of the physical interaction between estrogen receptor alpha and JUN proteins". J. Biol. Chem. 276 (39): 36361–9. doi:10.1074/jbc.M101806200. PMID 11477071.
• Lin SH, Arai AC, Wang Z, et al. (2001). "The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering". Mol. Pharmacol. 60 (5): 916–23. doi:10.1124/mol.60.5.916. PMID 11641419. S2CID 9613515.
• Hirbec H, Perestenko O, Nishimune A, et al. (2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". J. Biol. Chem. 277 (18): 15221–4. doi:10.1074/jbc.C200112200. hdl:2262/89271. PMID 11891216.
• Braithwaite SP, Xia H, Malenka RC (2002). "Differential roles for NSF and GRIP/ABP in AMPA receptor cycling". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 7096–101. Bibcode:2002PNAS...99.7096B. doi:10.1073/pnas.102156099. PMC 124534. PMID 12011465.
• Kotaja N, Karvonen U, Jänne OA, Palvimo JJ (2002). "The nuclear receptor interaction domain of GRIP1 is modulated by covalent attachment of SUMO-1". J. Biol. Chem. 277 (33): 30283–8. doi:10.1074/jbc.M204768200. PMID 12060666.
• Min G, Kim H, Bae Y, et al. (2002). "Inhibitory cross-talk between estrogen receptor (ER) and constitutively activated androstane receptor (CAR). CAR inhibits ER-mediated signaling pathway by squelching p160 coactivators". J. Biol. Chem. 277 (37): 34626–33. doi:10.1074/jbc.M205239200. PMID 12114525.
• Coutts AS, MacKenzie E, Griffith E, Black DM (2003). "TES is a novel focal adhesion protein with a role in cell spreading". J. Cell Sci. 116 (Pt 5): 897–906. doi:10.1242/jcs.00278. PMID 12571287. S2CID 26602119.
• Charych EI, Yu W, Li R, et al. (2004). "A four PDZ domain-containing splice variant form of GRIP1 is localized in GABAergic and glutamatergic synapses in the brain". J. Biol. Chem. 279 (37): 38978–90. doi:10.1074/jbc.M405786200. PMID 15226318.
• Sugatani J, Nishitani S, Yamakawa K, et al. (2005). "Transcriptional regulation of human UGT1A1 gene expression: activated glucocorticoid receptor enhances constitutive androstane receptor/pregnane X receptor-mediated UDP-glucuronosyltransferase 1A1 regulation with glucocorticoid receptor-interacting protein 1". Mol. Pharmacol. 67 (3): 845–55. doi:10.1124/mol.104.007161. PMID 15557560. S2CID 5742622.
• Lin DY, Fang HI, Ma AH, et al. (2004). "Negative Modulation of Androgen Receptor Transcriptional Activity by Daxx". Mol. Cell. Biol. 24 (24): 10529–41. doi:10.1128/MCB.24.24.10529-10541.2004. PMC 533990. PMID 15572661.
• Yang CK, Kim JH, Li H, Stallcup MR (2006). "Differential use of functional domains by CoCoA in its synergistic coactivator function with β-catenin or GRIP1". J. Biol. Chem. 281 (6): 3389–97. doi:10.1074/jbc.M510403200. PMC 1626527. PMID 16344550.
• Liu PY, Hsieh TY, Chou WY, Huang SM (2006). "Modulation of glucocorticoid receptor-interacting protein 1 (GRIP1) transactivation and co-activation activities through its C-terminal repression and self-association domains". FEBS J. 273 (10): 2172–83. doi:10.1111/j.1742-4658.2006.05231.x. PMID 16649994. S2CID 42365632.
• Tsai SJ, Liou YJ, Liao DL, et al. (2007). "No association of GRIP1 gene polymorphisms with schizophrenia in Chinese population". Prog. Neuropsychopharmacol. Biol. Psychiatry. 31 (3): 752–5. doi:10.1016/j.pnpbp.2007.01.015. PMID 17303296. S2CID 25981856.

External links

• Overview of all the structural information available in the PDB for UniProt: Q9Y3R0 (Human Glutamate receptor-interacting protein) at the PDBe-KB.
• Overview of all the structural information available in the PDB for UniProt: Q925T6 (Mouse Glutamate receptor-interacting protein) at the PDBe-KB.