The region of Tinker's Creek before European settlement was extremely valuable to Native Americans. This area is one of the highest points of the state and lies near the watershed divide in Ohio. The nearby Cuyahoga River flows north to Lake Erie, while the Tuscarawas (through the Muskingum) drains to the Ohio River. This proved advantageous as transportation by canoe from Lake Erie to the Ohio River was possible with only one 8-mile overland portage. The old Indian portage path traveled from the Cuyahoga to the Tuscarawas. This area became an important trade center for both pioneers and Indians. Cheesemaking was one of the early industries of the area (which was often referred to as Cheesedom. Nearly as soon as the first settlers arrived did cheesemaking commence. By 1834, northeast Ohio cheese controlled the southern markets. Eventually, canal and rail transportation increased the area's importance.

In the years prior to the state's acquisition of the land, the area was a private park known as Colonial Spring Gardens. The park was situated around a 10-acre, man-made lake and offered recreational opportunities. The state of Ohio purchased the land in 1966, and in May 1973, Tinker's Creek was dedicated as a state park.