FLOT1

Flotillin-1 is a protein that in humans is encoded by the FLOT1 gene.

FLOT1
Identifiers
Aliases	FLOT1, flotillin 1
External IDs	OMIM: 606998 MGI: 1100500 HomoloGene: 31337 GeneCards: FLOT1
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.33 Start 30,727,709 bp End 30,742,732 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 B1 Start 36,134,122 bp End 36,143,683 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal gland left adrenal gland blood dorsolateral prefrontal cortex left ventricle cerebellum cerebellar cortex cerebellar hemisphere Brodmann area 9 superior frontal gyrus Top expressed in interventricular septum right ventricle ankle joint sciatic nerve facial motor nucleus spinal ganglia visual cortex prefrontal cortex plantaris muscle entorhinal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protease binding protein binding protein heterodimerization activity ionotropic glutamate receptor binding Cellular component integral component of membrane endosome membrane cell-cell contact zone focal adhesion plasma membrane raft melanosome plasma membrane centriolar satellite microtubule organizing center lysosomal membrane flotillin complex uropod basolateral plasma membrane early endosome apical plasma membrane cortical actin cytoskeleton caveola membrane raft COP9 signalosome sarcolemma extracellular exosome cytoplasmic vesicle lamellipodium cell-cell junction external side of plasma membrane synapse presynaptic active zone dopaminergic synapse presynapse glutamatergic synapse GABA-ergic synapse Biological process positive regulation of cell-cell adhesion mediated by cadherin positive regulation of cell adhesion molecule production positive regulation of protein phosphorylation regulation of toll-like receptor 4 signaling pathway positive regulation of heterotypic cell-cell adhesion positive regulation of toll-like receptor 3 signaling pathway axonogenesis positive regulation of skeletal muscle tissue development positive regulation of cytokine production extracellular matrix disassembly protein kinase C signaling response to endoplasmic reticulum stress positive regulation of myoblast fusion positive regulation of endocytosis positive regulation of cell junction assembly protein localization to membrane raft membrane raft assembly cellular response to exogenous dsRNA regulation of receptor internalization positive regulation of synaptic transmission, dopaminergic positive regulation of protein binding regulation of Rho protein signal transduction protein homooligomerization dsRNA transport plasma membrane raft assembly positive regulation of interferon-beta production protein stabilization protein localization to plasma membrane regulation of neurotransmitter uptake positive regulation of NF-kappaB transcription factor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10211 14251 Ensembl ENSG00000137312 ENSG00000232280 ENSG00000224740 ENSG00000206480 ENSG00000206379 ENSG00000230143 ENSG00000236271 ENSG00000223654 ENSMUSG00000059714 UniProt O75955 O08917 RefSeq (mRNA) NM_005803 NM_001318875 NM_008027 RefSeq (protein) NP_001305804 NP_005794 NP_032053 Location (UCSC) Chr 6: 30.73 – 30.74 Mb Chr 17: 36.13 – 36.14 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. FLOT1 encodes a caveolae-associated, integral membrane protein. The function of flotillin 1 has not been determined.

Interactions

FLOT1 has been shown to interact with SORBS1.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Volonte D, Galbiati F, Li S, et al. (1999). "Flotillins/cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in vivo. Characterization and epitope-mapping of a novel flotillin-1 monoclonal antibody probe". J. Biol. Chem. 274 (18): 12702–9. doi:10.1074/jbc.274.18.12702. PMID 10212252.
• Hazarika P, Dham N, Patel P, et al. (1999). "Flotillin 2 is distinct from epidermal surface antigen (ESA) and is associated with filopodia formation". J. Cell. Biochem. 75 (1): 147–59. doi:10.1002/(SICI)1097-4644(19991001)75:1<147::AID-JCB15>3.0.CO;2-D. PMID 10462713. S2CID 12223151.
• Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
• Baumann CA, Ribon V, Kanzaki M, et al. (2000). "CAP defines a second signalling pathway required for insulin-stimulated glucose transport" (PDF). Nature. 407 (6801): 202–7. Bibcode:2000Natur.407..202B. doi:10.1038/35025089. hdl:2027.42/62940. PMID 11001060. S2CID 4334519.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Salzer U, Prohaska R (2001). "Stomatin, flotillin-1, and flotillin-2 are major integral proteins of erythrocyte lipid rafts". Blood. 97 (4): 1141–3. doi:10.1182/blood.V97.4.1141. PMID 11159550.
• Edgar AJ, Polak JM (2001). "Flotillin-1: gene structure: cDNA cloning from human lung and the identification of alternative polyadenylation signals". Int. J. Biochem. Cell Biol. 33 (1): 53–64. doi:10.1016/S1357-2725(00)00069-8. PMID 11167132.
• Kimura A, Baumann CA, Chiang SH, Saltiel AR (2001). "The sorbin homology domain: a motif for the targeting of proteins to lipid rafts". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 9098–103. Bibcode:2001PNAS...98.9098K. doi:10.1073/pnas.151252898. PMC 55379. PMID 11481476.
• Stuermer CA, Lang DM, Kirsch F, et al. (2002). "Glycosylphosphatidyl inositol-anchored proteins and fyn kinase assemble in noncaveolar plasma membrane microdomains defined by reggie-1 and -2". Mol. Biol. Cell. 12 (10): 3031–45. doi:10.1091/mbc.12.10.3031. PMC 60153. PMID 11598189.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Girardot N, Allinquant B, Duyckaerts C (2004). "[Lipid rafts, flotillin-1 and Alzheimer disease]". J. Soc. Biol. 197 (3): 223–9. doi:10.1051/jbio/2003197030223. PMID 14708344. S2CID 86221484.
• Wakasugi K, Nakano T, Kitatsuji C, Morishima I (2004). "Human neuroglobin interacts with flotillin-1, a lipid raft microdomain-associated protein". Biochem. Biophys. Res. Commun. 318 (2): 453–60. doi:10.1016/j.bbrc.2004.04.045. PMID 15120622.
• Haglund K, Ivankovic-Dikic I, Shimokawa N, et al. (2004). "Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites". J. Cell Sci. 117 (Pt 12): 2557–68. doi:10.1242/jcs.01148. PMID 15128873. S2CID 14083271.
• Bared SM, Buechler C, Boettcher A, et al. (2005). "Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells". Mol. Biol. Cell. 15 (12): 5399–407. doi:10.1091/mbc.E04-03-0182. PMC 532019. PMID 15469992.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Jacobowitz DM, Kallarakal AT (2005). "Flotillin-1 in the substantia nigra of the Parkinson brain and a predominant localization in catecholaminergic nerves in the rat brain". Neurotoxicity Research. 6 (4): 245–57. doi:10.1007/BF03033435. PMID 15545008. S2CID 22168131.
• Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin". J. Steroid Biochem. Mol. Biol. 94 (1–3): 203–8. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967. S2CID 9746088.
• Glebov OO, Bright NA, Nichols BJ (2006). "Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells". Nat. Cell Biol. 8 (1): 46–54. doi:10.1038/ncb1342. PMID 16341206. S2CID 36695735.

External links

• FLOT1 human gene location in the UCSC Genome Browser.
• FLOT1 human gene details in the UCSC Genome Browser.